Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 812395..813028 | Replicon | chromosome |
| Accession | NZ_CP046838 | ||
| Organism | Vibrio cholerae strain 2011EL-1271 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMA6 |
| Locus tag | GPY01_RS03680 | Protein ID | WP_000843587.1 |
| Coordinates | 812696..813028 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | GPY01_RS03675 | Protein ID | WP_000071011.1 |
| Coordinates | 812395..812709 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY01_RS03615 | 807824..808180 | - | 357 | WP_001094969.1 | hypothetical protein | - |
| GPY01_RS03620 | 808343..808783 | - | 441 | WP_001966102.1 | DUF1311 domain-containing protein | - |
| GPY01_RS18750 | 808827..808937 | - | 111 | WP_080308943.1 | DUF3265 domain-containing protein | - |
| GPY01_RS03630 | 808934..809251 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | - |
| GPY01_RS03635 | 809262..809549 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPY01_RS03640 | 809843..810085 | + | 243 | WP_001107720.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| GPY01_RS03645 | 810082..810381 | + | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPY01_RS03655 | 810498..810980 | - | 483 | WP_032471903.1 | GNAT family N-acetyltransferase | - |
| GPY01_RS03660 | 811007..811132 | - | 126 | WP_001973975.1 | DUF3265 domain-containing protein | - |
| GPY01_RS03665 | 811681..811923 | + | 243 | WP_000557291.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GPY01_RS03670 | 811942..812259 | + | 318 | WP_001180238.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPY01_RS03675 | 812395..812709 | - | 315 | WP_000071011.1 | DNA-binding transcriptional regulator | Antitoxin |
| GPY01_RS03680 | 812696..813028 | - | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPY01_RS03685 | 813219..813515 | - | 297 | WP_001069046.1 | hypothetical protein | - |
| GPY01_RS03690 | 813653..814078 | - | 426 | WP_119567070.1 | GNAT family N-acetyltransferase | - |
| GPY01_RS03695 | 814213..814638 | - | 426 | WP_119567070.1 | GNAT family N-acetyltransferase | - |
| GPY01_RS03700 | 814774..815514 | - | 741 | WP_032471918.1 | PhzF family phenazine biosynthesis protein | - |
| GPY01_RS03705 | 815570..815680 | - | 111 | Protein_718 | DUF3265 domain-containing protein | - |
| GPY01_RS03710 | 815677..816036 | - | 360 | WP_001071517.1 | VOC family protein | - |
| GPY01_RS03715 | 816277..816426 | - | 150 | WP_050498152.1 | DUF645 family protein | - |
| GPY01_RS03720 | 816723..817496 | - | 774 | WP_032471917.1 | aminoglycoside phosphotransferase family protein | - |
| GPY01_RS03725 | 817695..817874 | - | 180 | WP_080285482.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 781659..859428 | 77769 | |
| - | inside | Integron | - | - | 781069..851868 | 70799 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T145047 WP_000843587.1 NZ_CP046838:c813028-812696 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T145047 NZ_CP062250:c4569657-4569316 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11726.23 Da Isoelectric Point: 6.7600
>AT145047 WP_000071011.1 NZ_CP046838:c812709-812395 [Vibrio cholerae]
MSNRDLFTELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFTELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT145047 NZ_CP062250:4569652-4569728 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|