Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 808934..809549 | Replicon | chromosome |
| Accession | NZ_CP046838 | ||
| Organism | Vibrio cholerae strain 2011EL-1271 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMG5 |
| Locus tag | GPY01_RS03635 | Protein ID | WP_001162670.1 |
| Coordinates | 809262..809549 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | GPY01_RS03630 | Protein ID | WP_001232701.1 |
| Coordinates | 808934..809251 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY01_RS03575 | 804013..804177 | - | 165 | WP_123161798.1 | DUF645 family protein | - |
| GPY01_RS03580 | 804364..804489 | - | 126 | WP_001973975.1 | DUF3265 domain-containing protein | - |
| GPY01_RS03585 | 804949..805293 | - | 345 | WP_032471989.1 | hypothetical protein | - |
| GPY01_RS03590 | 805504..805675 | - | 172 | Protein_695 | DUF645 family protein | - |
| GPY01_RS18745 | 806039..806077 | - | 39 | WP_139151257.1 | hypothetical protein | - |
| GPY01_RS03595 | 806084..806221 | - | 138 | WP_002022145.1 | DUF645 family protein | - |
| GPY01_RS03600 | 806576..806821 | + | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| GPY01_RS03605 | 806821..807138 | + | 318 | WP_032471951.1 | CcdB family protein | - |
| GPY01_RS03610 | 807255..807680 | - | 426 | WP_119567070.1 | GNAT family N-acetyltransferase | - |
| GPY01_RS03615 | 807824..808180 | - | 357 | WP_001094969.1 | hypothetical protein | - |
| GPY01_RS03620 | 808343..808783 | - | 441 | WP_001966102.1 | DUF1311 domain-containing protein | - |
| GPY01_RS18750 | 808827..808937 | - | 111 | WP_080308943.1 | DUF3265 domain-containing protein | - |
| GPY01_RS03630 | 808934..809251 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | Antitoxin |
| GPY01_RS03635 | 809262..809549 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPY01_RS03640 | 809843..810085 | + | 243 | WP_001107720.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| GPY01_RS03645 | 810082..810381 | + | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPY01_RS03655 | 810498..810980 | - | 483 | WP_032471903.1 | GNAT family N-acetyltransferase | - |
| GPY01_RS03660 | 811007..811132 | - | 126 | WP_001973975.1 | DUF3265 domain-containing protein | - |
| GPY01_RS03665 | 811681..811923 | + | 243 | WP_000557291.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GPY01_RS03670 | 811942..812259 | + | 318 | WP_001180238.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPY01_RS03675 | 812395..812709 | - | 315 | WP_000071011.1 | DNA-binding transcriptional regulator | - |
| GPY01_RS03680 | 812696..813028 | - | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPY01_RS03685 | 813219..813515 | - | 297 | WP_001069046.1 | hypothetical protein | - |
| GPY01_RS03690 | 813653..814078 | - | 426 | WP_119567070.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 781659..859428 | 77769 | |
| - | inside | Integron | - | - | 781069..851868 | 70799 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T145044 WP_001162670.1 NZ_CP046838:c809549-809262 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T145044 NZ_CP062250:4342725-4342898 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT145044 WP_001232701.1 NZ_CP046838:c809251-808934 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT145044 NZ_CP062250:4342401-4342697 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|