144982

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1806080..1807436 Replicon chromosome
Accession NZ_CP046815
Organism Vibrio cincinnatiensis strain 1398-82

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag GPX87_RS08510 Protein ID WP_078927334.1
Coordinates 1806080..1807126 (-) Length 349 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag GPX87_RS08515 Protein ID WP_078927335.1
Coordinates 1807110..1807436 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPX87_RS08485 1801936..1802298 - 363 WP_078927329.1 conjugal transfer transcriptional regulator TraJ -
GPX87_RS08490 1802639..1802983 - 345 WP_078927330.1 TraK family protein -
GPX87_RS08495 1802985..1803224 - 240 WP_078927331.1 plasmid-related protein -
GPX87_RS08500 1804162..1805115 + 954 WP_078927332.1 toll/interleukin-1 receptor domain-containing protein -
GPX87_RS08505 1805202..1806032 + 831 WP_078927333.1 hypothetical protein -
GPX87_RS08510 1806080..1807126 - 1047 WP_078927334.1 HipA domain-containing protein Toxin
GPX87_RS08515 1807110..1807436 - 327 WP_078927335.1 HipA N-terminal domain-containing protein Antitoxin
GPX87_RS08520 1807421..1807741 - 321 WP_078927336.1 helix-turn-helix transcriptional regulator -
GPX87_RS08525 1808138..1809229 - 1092 WP_078927337.1 site-specific integrase -
GPX87_RS08535 1809546..1811417 - 1872 WP_078927338.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(60-309)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 349 a.a.        Molecular weight: 39606.98 Da        Isoelectric Point: 4.8226

>T144982 WP_078927334.1 NZ_CP046815:c1807126-1806080 [Vibrio cincinnatiensis]
MYPSNRSLISLDELNEQNREQVEYKKGEIKTLLGSNRFQIQLPFSRAEFVTELPKKQKGMSISGYQPKLSLAINEENQLG
VVEDKALFILKPSPEEFPNLAENEHATMLVMKSLGFDTPPFGLVRFNDKNGEGELAFIIRRYDRLNAGEEAIHQEQLDAA
MDVREKYGKTKGDTEGYVSYEQACKFLIDKVDGSLNFKKELFNRILVAYFLGNNDLHLRNIGLLLPEQEATRLAPIYDYV
SIAPYPDYIANENPLALPLLASEEGDNGNTSGYQSHCTYTGYDFLTFAQNIGLKPKLATKMINDLCAKQEAIIDIYRNSF
MPQEHVEKVAEWILSRINYLSQLEHVTI

Download         Length: 1047 bp

>T144982 NZ_CP062248:2759278-2760351 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12310.06 Da        Isoelectric Point: 4.8893

>AT144982 WP_078927335.1 NZ_CP046815:c1807436-1807110 [Vibrio cincinnatiensis]
MDRKVKVLLYGKFCGVLSQNEQGFTFEYEPSYKGRSLSLSMPVEDGPFESTELHPFFLSLAPEGWLKKRYSELQKIDEND
PLGMLLSNGKNLLGAVQLLRLEDHVSEQ

Download         Length: 327 bp

>AT144982 NZ_CP062248:2760344-2760715 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References