Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 117407..118140 | Replicon | chromosome |
| Accession | NZ_CP046812 | ||
| Organism | Vibrio alginolyticus strain 2010V-1102 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | GPY28_RS00575 | Protein ID | WP_053307311.1 |
| Coordinates | 117407..117724 (+) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | A0A0P7ER46 |
| Locus tag | GPY28_RS00580 | Protein ID | WP_025998577.1 |
| Coordinates | 117727..118140 (+) | Length | 138 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY28_RS00545 | 113272..114174 | + | 903 | WP_053307308.1 | homocysteine S-methyltransferase family protein | - |
| GPY28_RS00550 | 114161..115696 | + | 1536 | WP_053307309.1 | BCCT family transporter | - |
| GPY28_RS00555 | 115971..116253 | + | 283 | Protein_109 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GPY28_RS00560 | 116250..116536 | + | 287 | Protein_110 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPY28_RS00565 | 116664..116981 | - | 318 | WP_053307310.1 | CcdB family protein | - |
| GPY28_RS00570 | 116981..117226 | - | 246 | WP_025998575.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| GPY28_RS00575 | 117407..117724 | + | 318 | WP_053307311.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| GPY28_RS00580 | 117727..118140 | + | 414 | WP_025998577.1 | hypothetical protein | Antitoxin |
| GPY28_RS24895 | 118445..119170 | + | 726 | WP_199266775.1 | hypothetical protein | - |
| GPY28_RS00590 | 119194..119301 | + | 108 | WP_080996192.1 | DUF3265 domain-containing protein | - |
| GPY28_RS00595 | 119315..119710 | + | 396 | WP_053307313.1 | ACT domain-containing protein | - |
| GPY28_RS00600 | 119707..119907 | + | 201 | WP_080996182.1 | DUF3265 domain-containing protein | - |
| GPY28_RS00605 | 119886..121619 | + | 1734 | WP_053307314.1 | deoxycytidylate deaminase | - |
| GPY28_RS00610 | 121616..121726 | + | 111 | WP_080996193.1 | DUF3265 domain-containing protein | - |
| GPY28_RS00615 | 121771..122187 | + | 417 | Protein_121 | GNAT family N-acetyltransferase | - |
| GPY28_RS00620 | 122174..122304 | + | 131 | Protein_122 | DUF3265 domain-containing protein | - |
| GPY28_RS00625 | 122333..122737 | + | 405 | WP_053307315.1 | hypothetical protein | - |
| GPY28_RS00630 | 122755..122844 | + | 90 | WP_079766096.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 116544..130022 | 13478 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12171.16 Da Isoelectric Point: 10.1262
>T144979 WP_053307311.1 NZ_CP046812:117407-117724 [Vibrio alginolyticus]
MHVIKREPFETTKRLYPQCAEALDSTFKTLKATKAKRPEQLKQLFPSLDNFKYVDKWYVIDIGGGSLRLIAFIEFTGGKC
FVKYIVTHAEYDKIADQHRTKGKRG
MHVIKREPFETTKRLYPQCAEALDSTFKTLKATKAKRPEQLKQLFPSLDNFKYVDKWYVIDIGGGSLRLIAFIEFTGGKC
FVKYIVTHAEYDKIADQHRTKGKRG
Download Length: 318 bp
>T144979 NZ_CP062248:2071051-2071425 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 138 a.a. Molecular weight: 15845.18 Da Isoelectric Point: 4.5932
>AT144979 WP_025998577.1 NZ_CP046812:117727-118140 [Vibrio alginolyticus]
MNIQALKTLSNEIHTAMPWLQGIRDHEQYLELMELMDTLVEDYEENHVLIDLLFPVLERYEEESEHFQEFNAHIDSLDTG
IATLRVLIDQYRLTLSDLPEIGGKSLVSLILSGKRQLTVGHIKALSERFGVPKHMFI
MNIQALKTLSNEIHTAMPWLQGIRDHEQYLELMELMDTLVEDYEENHVLIDLLFPVLERYEEESEHFQEFNAHIDSLDTG
IATLRVLIDQYRLTLSDLPEIGGKSLVSLILSGKRQLTVGHIKALSERFGVPKHMFI
Download Length: 414 bp
>AT144979 NZ_CP062248:2070594-2070962 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|