Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 1766494..1767127 | Replicon | chromosome |
| Accession | NZ_CP046791 | ||
| Organism | Vibrio navarrensis strain 2462-79 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMA6 |
| Locus tag | GPY30_RS07880 | Protein ID | WP_000843587.1 |
| Coordinates | 1766795..1767127 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | GPY30_RS07875 | Protein ID | WP_000071011.1 |
| Coordinates | 1766494..1766808 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY30_RS07830 | 1761623..1762156 | - | 534 | WP_158133554.1 | cysteine hydrolase | - |
| GPY30_RS07835 | 1762294..1763070 | - | 777 | WP_158133555.1 | choline kinase | - |
| GPY30_RS07840 | 1763217..1763738 | - | 522 | WP_000355893.1 | GNAT family N-acetyltransferase | - |
| GPY30_RS07845 | 1763887..1764627 | - | 741 | WP_158133556.1 | hypothetical protein | - |
| GPY30_RS07850 | 1764702..1764965 | - | 264 | WP_158133557.1 | hypothetical protein | - |
| GPY30_RS07855 | 1765085..1765246 | - | 162 | WP_158133558.1 | hypothetical protein | - |
| GPY30_RS07860 | 1765347..1765469 | - | 123 | WP_080289628.1 | DUF3265 domain-containing protein | - |
| GPY30_RS07865 | 1765921..1766355 | - | 435 | WP_148553404.1 | GNAT family N-acetyltransferase | - |
| GPY30_RS07870 | 1766387..1766497 | - | 111 | WP_080342631.1 | DUF3265 domain-containing protein | - |
| GPY30_RS07875 | 1766494..1766808 | - | 315 | WP_000071011.1 | DNA-binding transcriptional regulator | Antitoxin |
| GPY30_RS07880 | 1766795..1767127 | - | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPY30_RS07885 | 1767166..1767306 | - | 141 | WP_158134925.1 | DUF3265 domain-containing protein | - |
| GPY30_RS07890 | 1768526..1768651 | - | 126 | WP_071919811.1 | DUF3265 domain-containing protein | - |
| GPY30_RS07895 | 1768880..1769140 | - | 261 | WP_158133559.1 | hypothetical protein | - |
| GPY30_RS07900 | 1769295..1769774 | - | 480 | WP_158133560.1 | GNAT family N-acetyltransferase | - |
| GPY30_RS07905 | 1770562..1770752 | - | 191 | Protein_1502 | DUF3709 domain-containing protein | - |
| GPY30_RS07910 | 1770773..1770939 | - | 167 | Protein_1503 | DUF3709 domain-containing protein | - |
| GPY30_RS07915 | 1770914..1771039 | - | 126 | WP_158133561.1 | DUF3265 domain-containing protein | - |
| GPY30_RS07920 | 1771382..1771522 | - | 141 | WP_154116352.1 | DUF3265 domain-containing protein | - |
| GPY30_RS07925 | 1771489..1771965 | - | 477 | WP_158133562.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | VP1611 / katB | 1589386..2075475 | 486089 | |
| - | inside | Integron | - | - | 1759479..1890842 | 131363 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T144940 WP_000843587.1 NZ_CP046791:c1767127-1766795 [Vibrio navarrensis]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T144940 NZ_CP062247:c242726-242448 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11726.23 Da Isoelectric Point: 6.7600
>AT144940 WP_000071011.1 NZ_CP046791:c1766808-1766494 [Vibrio navarrensis]
MSNRDLFTELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFTELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT144940 NZ_CP062247:c242989-242729 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|