Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 642509..643124 | Replicon | chromosome |
| Accession | NZ_CP046743 | ||
| Organism | Vibrio cholerae strain 3569-08 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMG5 |
| Locus tag | GPW72_RS03240 | Protein ID | WP_001162670.1 |
| Coordinates | 642837..643124 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | GPW72_RS03235 | Protein ID | WP_001232701.1 |
| Coordinates | 642509..642826 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPW72_RS03190 | 637601..638056 | - | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
| GPW72_RS03195 | 638186..639061 | - | 876 | WP_000259044.1 | hypothetical protein | - |
| GPW72_RS03205 | 639508..639990 | - | 483 | WP_001895003.1 | hypothetical protein | - |
| GPW72_RS03210 | 640047..640877 | - | 831 | WP_000056616.1 | abortive infection family protein | - |
| GPW72_RS03215 | 641082..641822 | - | 741 | WP_000469836.1 | PhzF family phenazine biosynthesis protein | - |
| GPW72_RS03220 | 642046..642084 | - | 39 | WP_106019119.1 | hypothetical protein | - |
| GPW72_RS03225 | 642100..642225 | - | 126 | WP_001944767.1 | DUF645 family protein | - |
| GPW72_RS19210 | 642402..642512 | - | 111 | WP_134814058.1 | DUF3265 domain-containing protein | - |
| GPW72_RS03235 | 642509..642826 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | Antitoxin |
| GPW72_RS03240 | 642837..643124 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPW72_RS03245 | 643391..643571 | - | 181 | Protein_617 | DUF645 family protein | - |
| GPW72_RS03250 | 643996..644229 | - | 234 | WP_032482776.1 | DUF3709 domain-containing protein | - |
| GPW72_RS03255 | 644632..644850 | - | 219 | WP_001917086.1 | DUF3709 domain-containing protein | - |
| GPW72_RS03260 | 645160..645813 | - | 654 | WP_000226874.1 | hypothetical protein | - |
| GPW72_RS03265 | 645870..646379 | - | 510 | WP_000405987.1 | GNAT family N-acetyltransferase | - |
| GPW72_RS03270 | 646621..646863 | + | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GPW72_RS03275 | 646882..647199 | + | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPW72_RS19215 | 647393..647488 | - | 96 | WP_001907607.1 | DUF645 family protein | - |
| GPW72_RS03285 | 647729..647839 | - | 111 | Protein_625 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 575627..724145 | 148518 | |
| - | inside | Integron | - | - | 575627..717201 | 141574 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T144876 WP_001162670.1 NZ_CP046743:c643124-642837 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T144876 NZ_CP062244:c2904450-2904115 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT144876 WP_001232701.1 NZ_CP046743:c642826-642509 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT144876 NZ_CP062244:c2904698-2904450 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|