Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 540921..541536 | Replicon | chromosome |
Accession | NZ_CP046741 | ||
Organism | Vibrio cholerae strain 3523-03 |
Toxin (Protein)
Gene name | higB | Uniprot ID | Q9KMG5 |
Locus tag | GPW86_RS02785 | Protein ID | WP_001162670.1 |
Coordinates | 540921..541208 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | GPW86_RS02790 | Protein ID | WP_001232701.1 |
Coordinates | 541219..541536 (+) | Length | 106 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GPW86_RS02735 | 537022..537273 | + | 252 | WP_123011643.1 | hypothetical protein | - |
GPW86_RS02740 | 537270..537485 | + | 216 | WP_123011644.1 | hypothetical protein | - |
GPW86_RS02745 | 537634..538341 | + | 708 | WP_001893912.1 | HAD family hydrolase | - |
GPW86_RS02750 | 538467..538733 | + | 267 | WP_000589156.1 | BrnT family toxin | - |
GPW86_RS02755 | 538720..538965 | + | 246 | WP_000643600.1 | hypothetical protein | - |
GPW86_RS02760 | 539143..539427 | + | 285 | WP_000048765.1 | antibiotic biosynthesis monooxygenase | - |
GPW86_RS02765 | 539565..539834 | - | 270 | WP_000277238.1 | type II toxin-antitoxin system YafQ family toxin | - |
GPW86_RS02770 | 539827..540105 | - | 279 | WP_001258569.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
GPW86_RS02775 | 540588..540638 | + | 51 | Protein_531 | DUF645 family protein | - |
GPW86_RS02785 | 540921..541208 | + | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
GPW86_RS02790 | 541219..541536 | + | 318 | WP_001232701.1 | HigA family addiction module antidote protein | Antitoxin |
GPW86_RS19365 | 541837..542035 | + | 199 | Protein_534 | DUF645 family protein | - |
GPW86_RS02805 | 542377..542556 | + | 180 | WP_032470611.1 | DUF645 family protein | - |
GPW86_RS02810 | 542798..543121 | + | 324 | WP_080476600.1 | DUF3709 domain-containing protein | - |
GPW86_RS02815 | 543440..543955 | + | 516 | WP_000284464.1 | hypothetical protein | - |
GPW86_RS02820 | 544012..544206 | + | 195 | WP_123011647.1 | DUF3709 domain-containing protein | - |
GPW86_RS02825 | 544242..544460 | + | 219 | WP_184476335.1 | DUF3709 domain-containing protein | - |
GPW86_RS02830 | 544729..545288 | + | 560 | Protein_540 | nucleotidyltransferase domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integron | - | - | 444653..571022 | 126369 | |
- | inside | Genomic island | - | - | 443489..637173 | 193684 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T144856 WP_001162670.1 NZ_CP046741:540921-541208 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T144856 NZ_CP062243:4439716-4440066 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT144856 WP_001232701.1 NZ_CP046741:541219-541536 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT144856 NZ_CP062243:4439471-4439722 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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