Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 1153230..1153882 Replicon plasmid pLLRS-1
Accession NZ_CP046730
Organism Ralstonia syzygii strain LLRS-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GO998_RS21465 Protein ID WP_211905164.1
Coordinates 1153538..1153882 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GO998_RS21460 Protein ID WP_075465945.1
Coordinates 1153230..1153541 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GO998_RS21445 (GO998_21425) 1148453..1148755 - 303 WP_211905162.1 hypothetical protein -
GO998_RS21450 (GO998_21430) 1148931..1150790 - 1860 WP_211905163.1 3'-5' exonuclease -
GO998_RS21455 (GO998_21435) 1152263..1153090 + 828 WP_075468526.1 DUF2242 domain-containing protein -
GO998_RS21460 (GO998_21440) 1153230..1153541 - 312 WP_075465945.1 transcriptional regulator Antitoxin
GO998_RS21465 (GO998_21445) 1153538..1153882 - 345 WP_211905164.1 toxin Toxin
GO998_RS21470 (GO998_21450) 1153933..1155870 - 1938 WP_075465941.1 propionate catabolism operon regulatory protein PrpR -
GO998_RS21475 (GO998_21455) 1156064..1156960 + 897 WP_211905165.1 methylisocitrate lyase -
GO998_RS21480 (GO998_21460) 1156995..1158158 + 1164 WP_211905166.1 2-methylcitrate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - acrB / fliI / fliG / fliM / flgG / flgC / cyaB / cheY / motA / cheW / cheB / cheY / adeG 1..2046405 2046405


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13408.06 Da        Isoelectric Point: 6.4857

>T144822 WP_211905164.1 NZ_CP046730:c1153882-1153538 [Ralstonia syzygii]
MDATFIELPPFQRLREHYLSDDEYRALQQELLAQPDAGDVIRGTSGLRKLRFSDKRRGKGKRGGLRVIYYHWDEGGQFWM
FAVYDKDEADDLSSDERKVLARLLEQEVKARSER

Download         Length: 345 bp

>T144822 NZ_CP062242:c2904450-2904115 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11575.53 Da        Isoelectric Point: 10.7132

>AT144822 WP_075465945.1 NZ_CP046730:c1153541-1153230 [Ralstonia syzygii]
MKRNLFAELKEGMDALAAEREGKTTLRKVKVRVLQPVDVTAEEIKAVRAAAHASQAVMARRLRVNVRTYQNWEQGTAKPN
TQAAVLIKLVEKHPETLQMLEAL

Download         Length: 312 bp

>AT144822 NZ_CP062242:c2904698-2904450 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References