144808

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2971259..2971907 Replicon chromosome
Accession NZ_CP046728
Organism Mycobacterium tuberculosis strain TCDC11

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag GP477_RS13915 Protein ID WP_003899414.1
Coordinates 2971259..2971582 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag GP477_RS13920 Protein ID WP_003899415.1
Coordinates 2971662..2971907 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GP477_RS13885 2966582..2967580 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
GP477_RS13890 2967594..2968058 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
GP477_RS13895 2968046..2968297 + 252 WP_003908028.1 hypothetical protein -
GP477_RS13900 2968468..2969907 - 1440 WP_003901443.1 phage major capsid protein -
GP477_RS13905 2969915..2970448 - 534 WP_003899412.1 HK97 family phage prohead protease -
GP477_RS13910 2970601..2971092 - 492 WP_003900541.1 phage terminase small subunit P27 family -
GP477_RS13915 2971259..2971582 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
GP477_RS13920 2971662..2971907 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
GP477_RS13925 2971904..2973331 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
GP477_RS13930 2973333..2973725 - 393 WP_003899417.1 DUF2742 domain-containing protein -
GP477_RS13935 2973722..2973982 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
GP477_RS13940 2973999..2974361 - 363 WP_003900543.1 hypothetical protein -
GP477_RS13945 2974364..2975491 - 1128 WP_003899420.1 site-specific integrase -
GP477_RS13950 2975636..2975863 - 228 WP_003899421.1 hypothetical protein -
GP477_RS13955 2975860..2976249 - 390 WP_003899422.1 hypothetical protein -
GP477_RS13960 2976155..2976427 + 273 WP_003900544.1 hypothetical protein -
GP477_RS13965 2976526..2976759 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2966582..2975491 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T144808 WP_003899414.1 NZ_CP046728:c2971582-2971259 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T144808 NZ_CP062242:c475764-475546 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT144808 WP_003899415.1 NZ_CP046728:c2971907-2971662 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT144808 NZ_CP062242:c476164-475790 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References