Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3726442..3727094 Replicon chromosome
Accession NZ_CP046722
Organism Pantoea agglomerans strain ASB05

Toxin (Protein)


Gene name higB Uniprot ID A0A8X8DRT2
Locus tag PAASB05_RS17365 Protein ID WP_010672045.1
Coordinates 3726442..3726795 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8X8DRN0
Locus tag PAASB05_RS17370 Protein ID WP_010252120.1
Coordinates 3726795..3727094 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAASB05_RS17350 3722168..3723952 - 1785 WP_010672042.1 GMC family oxidoreductase -
PAASB05_RS17355 3723955..3724689 - 735 WP_010672043.1 gluconate 2-dehydrogenase subunit 3 family protein -
PAASB05_RS17360 3724966..3726207 + 1242 WP_158132071.1 peptide antibiotic transporter SbmA -
PAASB05_RS17365 3726442..3726795 + 354 WP_010672045.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PAASB05_RS17370 3726795..3727094 + 300 WP_010252120.1 XRE family transcriptional regulator Antitoxin
PAASB05_RS17375 3727216..3728268 - 1053 WP_010672046.1 YncE family protein -
PAASB05_RS17380 3728471..3728680 - 210 WP_009092571.1 DUF1471 domain-containing protein -
PAASB05_RS17385 3728893..3730080 - 1188 WP_010252123.1 MFS transporter -
PAASB05_RS17390 3730186..3731151 + 966 WP_033770846.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13660.67 Da        Isoelectric Point: 7.9792

>T144756 WP_010672045.1 NZ_CP046722:3726442-3726795 [Pantoea agglomerans]
MWTVLLSPRFESWLSEQEEALQEKMLADLGKLKVYGPDLPRPYADTLKGSQYRNMKELRVQFSGKPIRAFYAFDPVRQAI
VLCAGDKSHDKRFYIRMIRIADDEFSAWLAEQEKGNN

Download         Length: 354 bp

>T144756 NZ_CP062240:c1265266-1265159 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11116.99 Da        Isoelectric Point: 6.3781

>AT144756 WP_010252120.1 NZ_CP046722:3726795-3727094 [Pantoea agglomerans]
MRTLDDVIADFSPESQARIKKMSDEMILEVGLQMIREELQLSQKTLAEAMGVRQPAVAQIEQRGNEIKVATLKRYVEAMG
GKLSLDVELPTGKRVAFRI

Download         Length: 300 bp

>AT144756 NZ_CP062240:1265313-1265379 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References