Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1748720..1749450 Replicon chromosome
Accession NZ_CP046722
Organism Pantoea agglomerans strain ASB05

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PAASB05_RS08030 Protein ID WP_010258579.1
Coordinates 1749133..1749450 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PAASB05_RS08025 Protein ID WP_010258577.1
Coordinates 1748720..1749052 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAASB05_RS08005 1744098..1744739 + 642 WP_003849160.1 protein phosphatase CheZ -
PAASB05_RS08010 1744928..1746079 + 1152 WP_033772015.1 flagellar type III secretion system protein FlhB -
PAASB05_RS08015 1746072..1748165 + 2094 WP_010258569.1 flagellar biosynthesis protein FlhA -
PAASB05_RS08020 1748165..1748557 + 393 WP_022625502.1 flagellar protein FlhE -
PAASB05_RS08025 1748720..1749052 - 333 WP_010258577.1 HigA family addiction module antidote protein Antitoxin
PAASB05_RS08030 1749133..1749450 - 318 WP_010258579.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PAASB05_RS08035 1749525..1750523 - 999 WP_158131623.1 aldo/keto reductase -
PAASB05_RS08040 1750736..1751671 - 936 WP_158131624.1 LysR family transcriptional regulator -
PAASB05_RS08045 1751759..1753489 - 1731 WP_010258588.1 arginine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12357.17 Da        Isoelectric Point: 10.1380

>T144751 WP_010258579.1 NZ_CP046722:c1749450-1749133 [Pantoea agglomerans]
VATLRNIESFRDDWLKDYFLYGKFSKRIPSSLSSALARKLDMINAAINYKDLRSPPGNRYEELNPPLKGYASIRVNEQYR
LIFKWIEGKAVDLYLDAHSYKTHKR

Download         Length: 318 bp

>T144751 NZ_CP062240:c242726-242448 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12615.48 Da        Isoelectric Point: 5.1473

>AT144751 WP_010258577.1 NZ_CP046722:c1749052-1748720 [Pantoea agglomerans]
MNQATRKPTTVGDVLLYEYLEPTGLKILDLAEMLKVHRNTVSALVNNNRKLTPDMAFRLAAAFETSVEFWLNLQNSVDIW
EVMHDARAQEEISRVTPLKDFLVQKENQLA

Download         Length: 333 bp

>AT144751 NZ_CP062240:c242989-242729 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References