Detailed information of TA system TA144750

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1560981..1561641
• Replicon: chromosome
• Accession: NZ_CP046722
• Organism: Pantoea agglomerans strain ASB05

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: PAASB05_RS07175
• Protein ID: WP_158131587.1
• Coordinates: 1560981..1561334 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: PAASB05_RS07180
• Protein ID: WP_010247918.1
• Coordinates: 1561339..1561641 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PAASB05_RS07155	1556178..1556459	+	282	WP_010247933.1	hypothetical protein	-
PAASB05_RS07160	1556558..1556959	+	402	WP_010247930.1	hypothetical protein	-
PAASB05_RS07165	1557036..1559198	-	2163	WP_158131586.1	ferric-rhodotorulic acid/ferric-coprogen receptor FhuE	-
PAASB05_RS07170	1559594..1560682	+	1089	WP_029519619.1	hypothetical protein	-
PAASB05_RS07175	1560981..1561334	+	354	WP_158131587.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PAASB05_RS07180	1561339..1561641	+	303	WP_010247918.1	XRE family transcriptional regulator	Antitoxin
PAASB05_RS07190	1562313..1563236	+	924	WP_010247907.1	sugar ABC transporter substrate-binding protein	-
PAASB05_RS07195	1563269..1564753	+	1485	WP_010247905.1	sugar ABC transporter ATP-binding protein	-
PAASB05_RS07200	1564777..1565802	+	1026	WP_174819610.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (18-89)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13640.70 Da
• Isoelectric Point: 8.4885

>T144750 WP_158131587.1 NZ_CP046722:1560981-1561334 [Pantoea agglomerans]
VWMIKTTERFDRWFTLLNESDRACVLAALMVLREKGPGLSRPYADTLKGSVYINMKELRIQSRGDPIRAFFAFDPNRTAI
VLCAGNKVGNEKRFYQEMLPVADREFTQWLNSFKDEE

Nucleotide

• Length: 354 bp

>T144750 NZ_CP062239:c4569657-4569316 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10941.72 Da
• Isoelectric Point: 5.7251

>AT144750 WP_010247918.1 NZ_CP046722:1561339-1561641 [Pantoea agglomerans]
MGRTLEQLIADEKPEVVADAQAMATDILLNIHLAELREKVQKTQVEMAKALGITQPTVAGMEKPGRDLKLSTLKRYIDAA
GGKLRLVVELPDGSHYGFEV

Nucleotide

• Length: 303 bp

>AT144750 NZ_CP062239:4569652-4569728 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT