Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2070358..2070966 Replicon chromosome
Accession NZ_CP046703
Organism Nostoc sp. ATCC 53789

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GJB62_RS08435 Protein ID WP_114085305.1
Coordinates 2070682..2070966 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GJB62_RS08430 Protein ID WP_114085304.1
Coordinates 2070358..2070666 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJB62_RS08420 2065459..2066256 - 798 WP_114085302.1 Uma2 family endonuclease -
GJB62_RS08425 2066400..2070347 + 3948 WP_209271488.1 HEAT repeat domain-containing protein -
GJB62_RS08430 2070358..2070666 - 309 WP_114085304.1 HigA family addiction module antidote protein Antitoxin
GJB62_RS08435 2070682..2070966 - 285 WP_114085305.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJB62_RS08440 2071366..2072451 + 1086 WP_114085306.1 bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada -
GJB62_RS08445 2072435..2073073 + 639 WP_114085307.1 DNA-3-methyladenine glycosylase -
GJB62_RS08450 2073178..2074176 + 999 WP_114085308.1 DMT family transporter -
GJB62_RS08455 2074665..2075504 - 840 WP_114085309.1 diaminopimelate epimerase -
GJB62_RS08460 2075574..2075792 + 219 WP_041565643.1 RNA chaperone Hfq -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-83)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.40 Da        Isoelectric Point: 7.9985

>T144716 WP_114085305.1 NZ_CP046703:c2070966-2070682 [Nostoc sp. ATCC 53789]
VIVSFKSEETKLIFDGFTSSQYPPNIQKTALRKLLILDAATSINDLRVPPGNRLEKLLGNRKGQYSIRINNQWRICFVWT
DENNVSEVEIVDYH

Download         Length: 285 bp

>T144716 NZ_CP062231:1237492-1237797 [Rhizobium sp. TH2]
ATGCCGCTCTTCATCAAACAGGCGGAAGCCGTGTGGTCCATTGAGGAGCGCTCGGAATTCATCGACTTCATCGCTGGCAA
TCCGGAGGCCGGGGACTTGATCCCCGGCACCGGCGGCATTCGAAAGATCCGCTGGTCCCGGGGCGGAAGCGGAAAACGTG
GCGGCGTTCGTGTGATCTATTTCTTCTACGACGAAGTGAGGCCACTCTATTTGTTGATGGTTTATTCCAAAGCCCGAAAG
GAAAACTTGACGCCGGATGAAACGAAAATTCTGCGGAACATCGCCGCCGCGATTTCAAGAAAGTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11750.26 Da        Isoelectric Point: 4.7063

>AT144716 WP_114085304.1 NZ_CP046703:c2070666-2070358 [Nostoc sp. ATCC 53789]
MNNNRLPNIYPGEILQLEFLEPLNITPYRLSKDIGVAQTRISEILSGKRTITADTALRLSRYFGNSAQFWLNLQTQYDIR
QALEENAEVYNQIPTLSFNDVT

Download         Length: 309 bp

>AT144716 NZ_CP062231:1237807-1238100 [Rhizobium sp. TH2]
ATGGGACGGTTTGCAGACGAACTCATTGAGAGCATGACCCAGGCGCTGGATCATGCGCGAGGCAACAAGGTCGATGGAAT
GCGGTTGACGGAGGTTCATGTTCCCGATGTCAGGATCATCCGGGAATCGCTTCACATGTCGCAAAGCGAATTCGCTTCAA
GCTTTCGAATTCCGCTGGCAACCATAAAGAACTGGGAGCAGGGCAGGCGGCGGCCCGACGCACCGGCGCTCGCCTATCTT
CGCGTCATCGAGCGCAGTCCGAAGACTGTTATTGAGGCGGTAGCTACCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References