Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-HTH |
| Location | 42299..42973 | Replicon | plasmid pEGKP3.3 |
| Accession | NZ_CP046647 | ||
| Organism | Klebsiella pneumoniae strain EGKP3 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A5Q9LMS5 |
| Locus tag | GPU01_RS26880 | Protein ID | WP_032720638.1 |
| Coordinates | 42299..42622 (+) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | GPU01_RS26885 | Protein ID | WP_032720637.1 |
| Coordinates | 42671..42973 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPU01_RS26840 (GPU01_26465) | 37575..37940 | - | 366 | WP_001294656.1 | mercuric ion transporter MerT | - |
| GPU01_RS26845 (GPU01_26470) | 38012..38467 | + | 456 | WP_001166628.1 | Hg(II)-responsive transcriptional regulator | - |
| GPU01_RS26850 (GPU01_26475) | 38501..39049 | + | 549 | Protein_48 | SOS response-associated peptidase family protein | - |
| GPU01_RS26855 (GPU01_26480) | 39238..39411 | + | 174 | WP_153591447.1 | hypothetical protein | - |
| GPU01_RS26860 (GPU01_26485) | 39445..40142 | + | 698 | WP_223367361.1 | IS1 family transposase | - |
| GPU01_RS26865 (GPU01_26490) | 40640..41242 | + | 603 | Protein_51 | RNA-guided endonuclease TnpB family protein | - |
| GPU01_RS26870 | 41311..41738 | - | 428 | Protein_52 | DNA-binding protein | - |
| GPU01_RS26875 (GPU01_26495) | 41716..42121 | + | 406 | Protein_53 | DUF4113 domain-containing protein | - |
| GPU01_RS26880 (GPU01_26500) | 42299..42622 | + | 324 | WP_032720638.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPU01_RS26885 (GPU01_26505) | 42671..42973 | + | 303 | WP_032720637.1 | NadS family protein | Antitoxin |
| GPU01_RS26890 (GPU01_26510) | 43016..43183 | - | 168 | WP_153591440.1 | hypothetical protein | - |
| GPU01_RS26895 (GPU01_26515) | 43371..43577 | - | 207 | WP_153591439.1 | hypothetical protein | - |
| GPU01_RS26900 (GPU01_26520) | 43574..43957 | - | 384 | WP_032720636.1 | hypothetical protein | - |
| GPU01_RS26905 (GPU01_26525) | 44062..44634 | - | 573 | WP_032720635.1 | GNAT family N-acetyltransferase | - |
| GPU01_RS26910 (GPU01_26530) | 44636..45448 | - | 813 | WP_223203129.1 | TSUP family transporter | - |
| GPU01_RS26915 (GPU01_26535) | 45460..46380 | - | 921 | WP_050548604.1 | TauD/TfdA family dioxygenase | - |
| GPU01_RS26920 (GPU01_26540) | 46683..47177 | - | 495 | WP_044266755.1 | hypothetical protein | - |
| GPU01_RS26925 (GPU01_26545) | 47208..47780 | - | 573 | WP_044266753.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaNDM-1 / aph(3')-VI / qnrS1 / blaSHV-12 / aac(6')-Il / blaOXA-10 / qacE / sul1 | - | 1..154760 | 154760 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 12372.29 Da Isoelectric Point: 9.6240
>T144656 WP_032720638.1 NZ_CP046647:42299-42622 [Klebsiella pneumoniae]
MNYLEFVETSAFSGLRKELMDDDEFRELQTYLLEAHDRGDTISHTGGCRKIRWGRPGMGKRGGVRVIYYVRLASGRLYLL
LIYPKNAKDELSEKEKAVMKALTQQLK
MNYLEFVETSAFSGLRKELMDDDEFRELQTYLLEAHDRGDTISHTGGCRKIRWGRPGMGKRGGVRVIYYVRLASGRLYLL
LIYPKNAKDELSEKEKAVMKALTQQLK
Download Length: 324 bp
>T144656 NZ_CP062211:c2677966-2677863 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 101 a.a. Molecular weight: 11211.12 Da Isoelectric Point: 7.3611
>AT144656 WP_032720637.1 NZ_CP046647:42671-42973 [Klebsiella pneumoniae]
MEKKLFDALISSMEEMVAIENGQIQPAAEQVHRHTLPDVKAIRKHAGMKQAEFAEVVGASVDLVRSWEQQRRVPSGIALK
MLCLIEREPALINTLRGIHV
MEKKLFDALISSMEEMVAIENGQIQPAAEQVHRHTLPDVKAIRKHAGMKQAEFAEVVGASVDLVRSWEQQRRVPSGIALK
MLCLIEREPALINTLRGIHV
Download Length: 303 bp
>AT144656 NZ_CP062211:2677825-2678096 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|