Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1678020..1678720 Replicon chromosome
Accession NZ_CP046608
Organism Burkholderia contaminans strain XL73

Toxin (Protein)


Gene name mqsR Uniprot ID A0A1E3FT75
Locus tag GON15_RS14150 Protein ID WP_039357707.1
Coordinates 1678020..1678316 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A4R4BTY4
Locus tag GON15_RS14155 Protein ID WP_039357704.1
Coordinates 1678319..1678720 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GON15_RS14135 1674545..1676095 + 1551 WP_039357717.1 sensor domain-containing diguanylate cyclase -
GON15_RS14140 1676337..1676621 + 285 WP_039357714.1 hypothetical protein -
GON15_RS14145 1676873..1677916 + 1044 WP_039357711.1 succinylglutamate desuccinylase/aspartoacylase family protein -
GON15_RS14150 1678020..1678316 + 297 WP_039357707.1 type II toxin-antitoxin system MqsR family toxin Toxin
GON15_RS14155 1678319..1678720 + 402 WP_039357704.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
GON15_RS14160 1679039..1679599 + 561 WP_039357701.1 GNAT family N-acetyltransferase -
GON15_RS14165 1679656..1680603 + 948 WP_039357698.1 ABC transporter substrate-binding protein -
GON15_RS14170 1680656..1681705 + 1050 WP_039357696.1 LLM class flavin-dependent oxidoreductase -
GON15_RS14175 1681713..1683065 + 1353 WP_039357693.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(72-109)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11206.04 Da        Isoelectric Point: 8.0535

>T144575 WP_039357707.1 NZ_CP046608:1678020-1678316 [Burkholderia contaminans]
MEKRTPHCKLPRVKALVETGQVRLTASAVLGARLLGFTEREALDVVLSLTDLDFHKSMTTYADHTIWQDVYRPFTVRGDV
YLKLTVIDDVLIVSFKER

Download         Length: 297 bp

>T144575 NZ_CP062160:3245715-3245822 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14649.94 Da        Isoelectric Point: 8.8304

>AT144575 WP_039357704.1 NZ_CP046608:1678319-1678720 [Burkholderia contaminans]
MKCPACGAARLVRDTRDIPYTYKGRSTVVRDITGDFCPACGESVLDLDEATRLGEAITEFNKQVNATIVDPKYIAKVRKK
LKLDQREAAELFGGGVNAFSRYETGKTNPPLALVKLLKLLDRHPDLLAEVRAA

Download         Length: 402 bp

>AT144575 NZ_CP062160:c3245667-3245608 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FT75

Antitoxin

Source ID Structure
AlphaFold DB A0A4R4BTY4

References