Detailed information of TA system TA144558

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-as-bsrH/-
• Location: 2561529..2561846
• Replicon: chromosome
• Accession: NZ_CP046592
• Organism: Bacillus subtilis strain TR21

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: P54373
• Locus tag: GO005_RS13185
• Protein ID: WP_004398662.1
• Coordinates: 2561529..2561708 (+)
• Length: 60 a.a.

Antitoxin (RNA)

Gene name	as-bsrH
Locus tag	-
Coordinates	2561632..2561846 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GO005_RS13175	2560755..2560892	-	138	WP_021480099.1	hypothetical protein	-
GO005_RS13180	2560934..2561383	-	450	WP_032722171.1	phage portal protein	-
GO005_RS13185	2561529..2561708	+	180	WP_004398662.1	type I toxin-antitoxin system toxin TxpA	Toxin
-	2561632..2561846	-	215	NuclAT_0	-	Antitoxin
-	2561632..2561846	-	215	NuclAT_0	-	Antitoxin
-	2561632..2561846	-	215	NuclAT_0	-	Antitoxin
-	2561632..2561846	-	215	NuclAT_0	-	Antitoxin
GO005_RS13190	2562080..2562169	+	90	WP_075058862.1	type I toxin-antitoxin system toxin BsrH	-
GO005_RS13195	2562423..2562866	-	444	WP_003229930.1	phage tail tube protein	-
GO005_RS13200	2562869..2564269	-	1401	WP_003229929.1	phage tail sheath family protein	-
GO005_RS13205	2564270..2564461	-	192	WP_010886574.1	hypothetical protein	-
GO005_RS13210	2564458..2564895	-	438	WP_003229927.1	hypothetical protein	-
GO005_RS13215	2564908..2565411	-	504	WP_003246050.1	HK97 gp10 family phage protein	-
GO005_RS13220	2565408..2565770	-	363	WP_003229925.1	YqbH/XkdH family protein	-
GO005_RS13225	2565767..2566162	-	396	WP_004398566.1	DUF3199 family protein	-
GO005_RS13230	2566166..2566477	-	312	WP_003229923.1	YqbF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2536279..2587592	51313

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6739.19 Da
• Isoelectric Point: 8.0370

>T144558 WP_004398662.1 NZ_CP046592:2561529-2561708 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Nucleotide

• Length: 180 bp

>T144558 NZ_CP062158:2748106-2748402 [Pseudomonas lundensis]
ATGGAGAAAAAGACCCCGCACTGCAAACTACACACCGTTAAAGCCCTGATTGAAGCGGGCAAGGTGCGCTCTACCCTGTC
AGCACTGACCGGTGGCGCGGCTTTAGGCTTCGACTTTGACGGCATCGTCAGCGTGGTAATGGCACTGGCGCCCGCTGACT
TTTACAAAAGCATGACCACGCACGCCGACCACAAGGTCTGGCAGGACGTGTACCGGCGTAAAACCCAAGCCGGCGAGGTC
TACCTCAAACTCACGGTCATTGATGATGTGCTCATCGTGTCCTTCAAGGAGCTATGA

Antitoxin

Nucleotide

• Length: 215 bp

>AT144558 NZ_CP046592:c2561846-2561632 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACTTGTTAATGTGTGTTACTTTCATG
AGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAGGAGGGTCC
TCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Structures

Toxin

• AlphaFold DB: A0A164X333

Antitoxin