Detailed information of TA system TA144549

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe(toxin)
• Location: 96792..97303
• Replicon: chromosome
• Accession: NZ_CP046590
• Organism: Macrococcus canis strain LI021

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: GOY09_RS00545
• Protein ID: WP_210151720.1
• Coordinates: 96792..97052 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: GOY09_RS00550
• Protein ID: WP_086042489.1
• Coordinates: 97052..97303 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GOY09_RS00505 (GOY09_00505)	91843..92379	-	537	WP_210151727.1	GrpB family protein	-
GOY09_RS00510 (GOY09_00510)	92651..92908	+	258	WP_211553163.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
GOY09_RS00515 (GOY09_00515)	92901..93173	+	273	WP_211553165.1	Txe/YoeB family addiction module toxin	-
GOY09_RS00520 (GOY09_00520)	93196..93957	-	762	WP_211553167.1	hypothetical protein	-
GOY09_RS00525 (GOY09_00525)	93963..94448	-	486	WP_211553169.1	NUDIX domain-containing protein	-
GOY09_RS00530 (GOY09_00530)	94622..95512	-	891	WP_211553171.1	phosphotransferase	-
GOY09_RS00535 (GOY09_00535)	95522..96262	-	741	WP_211553173.1	hypothetical protein	-
GOY09_RS00540 (GOY09_00540)	96342..96791	+	450	WP_211553175.1	GNAT family N-acetyltransferase	-
GOY09_RS00545 (GOY09_00545)	96792..97052	-	261	WP_210151720.1	Txe/YoeB family addiction module toxin	Toxin
GOY09_RS00550 (GOY09_00550)	97052..97303	-	252	WP_086042489.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GOY09_RS00555 (GOY09_00555)	98003..98914	-	912	WP_210151718.1	hypothetical protein	-
GOY09_RS00560 (GOY09_00560)	98944..99324	-	381	WP_211553177.1	sporulation protein	-
GOY09_RS00565 (GOY09_00565)	99486..100490	+	1005	WP_211553179.1	cation diffusion facilitator family transporter	-
GOY09_RS00570 (GOY09_00570)	100539..100727	+	189	WP_086042483.1	2-hydroxymuconate tautomerase	-
GOY09_RS00575 (GOY09_00575)	100765..101706	-	942	WP_211553181.1	LCP family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-59)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10245.91 Da
• Isoelectric Point: 10.1613

>T144549 WP_210151720.1 NZ_CP046590:c97052-96792 [Macrococcus canis]
MYKIVLKSSVKKDLKKIKNTLLETNFLKIINQLKENPYNNNHSFEKLIPPIKGFYSRRINVQHRVVYTVNDEDKIVTIYS
AYGHYE

Nucleotide

• Length: 261 bp

>T144549 NZ_CP062147:c3208756-3208346 [Komagataeibacter hansenii]
ATGCTGCGTTACCTGCTGGATACGAACCTCTGTATCCGGGTATTGCGAGATCGGCCGCAGGGGCTGCGTCCGAGGTTCAA
CAACTGTGCGGAGGAACTCTGCATCTCGGACGTGGTTCTGTATGAACTGCTTTATGGCGCGGAACGCTCGTCTGATCCCG
TGCGCACAAGACGTGAGGTCGAGCACTTTGCTGCAAGGCTGGCGATCCTGCCATTCGACAGTGAAGCGGCCGCCCATACG
GCAGACATTCGGGCCGAACTTGAACGGAATGGCCGTATCATAGGTCCATATGATCTCATGATTGCCGGGCATGCCCGGAG
CAGAGGGCTGATTGTGGTGACCGGCAATCTGCGAGAATTTCAGCGGGTAGAGGGTCTTCGAACCGAGGACTGGCTGACTG
ACACGGTCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9590.65 Da
• Isoelectric Point: 4.0373

>AT144549 WP_086042489.1 NZ_CP046590:c97303-97052 [Macrococcus canis]
MNTYTPTSARKDFFNIIKSVNEDSKEIYIAPTKIGEKGAVLVGEDDWNAIQETLFLLEKGIAYQIEQRKDEEEIDFDSTW
DNI

Nucleotide

• Length: 252 bp

>AT144549 NZ_CP062147:c3208981-3208757 [Komagataeibacter hansenii]
ATGCTGACCCGTACGACACTCTTTCTATCCAACCGCTCGCAGGCAGTGCGTCTGCCGAAGATGGTCGCCTTCGGGGAGCA
GGTGCGTGACGTCGTCATTATGTCCGAAGGTTCACGACGGATCATCGCCCCCGCTGACGCAGCGTGGGATGATTTCTTTG
CGGCTCCCAGGGTGGATCTGGGAGAGCGGAACCAGCCGGCCATGCAGGAACGTGAGGCGCTCTGA