Detailed information of TA system TA144548

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 92651..93173
• Replicon: chromosome
• Accession: NZ_CP046590
• Organism: Macrococcus canis strain LI021

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: GOY09_RS00515
• Protein ID: WP_211553165.1
• Coordinates: 92901..93173 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: GOY09_RS00510
• Protein ID: WP_211553163.1
• Coordinates: 92651..92908 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GOY09_RS00480 (GOY09_00480)	88994..90094	-	1101	WP_211553157.1	DUF1648 domain-containing protein	-
GOY09_RS00485 (GOY09_00485)	90094..90462	-	369	WP_211553159.1	GntR family transcriptional regulator	-
GOY09_RS00490 (GOY09_00490)	90558..91025	-	468	WP_211553161.1	hypothetical protein	-
GOY09_RS00495 (GOY09_00495)	91187..91387	-	201	WP_210151728.1	HAD family hydrolase	-
GOY09_RS00500 (GOY09_00500)	91389..91838	-	450	WP_233455643.1	GNAT family N-acetyltransferase	-
GOY09_RS00505 (GOY09_00505)	91843..92379	-	537	WP_210151727.1	GrpB family protein	-
GOY09_RS00510 (GOY09_00510)	92651..92908	+	258	WP_211553163.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GOY09_RS00515 (GOY09_00515)	92901..93173	+	273	WP_211553165.1	Txe/YoeB family addiction module toxin	Toxin
GOY09_RS00520 (GOY09_00520)	93196..93957	-	762	WP_211553167.1	hypothetical protein	-
GOY09_RS00525 (GOY09_00525)	93963..94448	-	486	WP_211553169.1	NUDIX domain-containing protein	-
GOY09_RS00530 (GOY09_00530)	94622..95512	-	891	WP_211553171.1	phosphotransferase	-
GOY09_RS00535 (GOY09_00535)	95522..96262	-	741	WP_211553173.1	hypothetical protein	-
GOY09_RS00540 (GOY09_00540)	96342..96791	+	450	WP_211553175.1	GNAT family N-acetyltransferase	-
GOY09_RS00545 (GOY09_00545)	96792..97052	-	261	WP_210151720.1	Txe/YoeB family addiction module toxin	-
GOY09_RS00550 (GOY09_00550)	97052..97303	-	252	WP_086042489.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (10-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10680.43 Da
• Isoelectric Point: 9.7524

>T144548 WP_211553165.1 NZ_CP046590:92901-93173 [Macrococcus canis]
MPKKKILFYSSGFEDYTYWQTNDKTVLKKINKLIKSIMIDGANEGIGKPEKLLGNYTGCYSRRITHEHRLVYKIDDDSIC
ILQCRFHYKR

Nucleotide

• Length: 273 bp

>T144548 NZ_CP062147:2281294-2281464 [Komagataeibacter hansenii]
ATCCGAAAGATCGAAGCCGCCGGATGGACGCACCGGAGAACCACAGGCAGCCATCACCACTTCCGGCATCCCGGGCGACC
CGGAACGGTGACAGTCCCCCCCCCCAAGAGAGACCTGCCAAAAGGCACCCTCCGCAGCATAGAAAAACAGTCAGGAGTAT
CTTTAAAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9693.74 Da
• Isoelectric Point: 4.1541

>AT144548 WP_211553163.1 NZ_CP046590:92651-92908 [Macrococcus canis]
MKVTTYSNARSNFRKIIDIVNEDSEPYTITTNTHNAVILSEQDYNSMIETLYLQSTPANAERLQKAIDESIDKNNLLQVE
IDLDA

Nucleotide

• Length: 258 bp

>AT144548 NZ_CP062147:2281461-2281853 [Komagataeibacter hansenii]
ATGACCAATTATATCGGACTGATCCGCAAAGACGCTGAAAGTGATTTCGGGGTTGATTTCCCCGATTTCCCCGGATGCGT
ATCAGCCGGGGGCACGCTTGATGAGGCGCGGGTAATGGGTCAGGAGGCCCTTTCAGGGCATATCGACTGCATGCGGGAAG
ATGGTGATGCCATTCCCGCCCCGTCTTCTCTGGAAGACATTATGTCTGATCCAGACAACCGGGATGCCGTAGCTTTTCTG
GTTGTAGTTCCAGAGAGTGACCGCCTGATCCGGGTGAACGTCACTCTGGAAGAGTCGCTTCTTAAGGCGATAAAGGGAGC
GGCTGAAAACCGGTCCCGGTTCCTGTCTATTGCGGCGCGGGAGAAACTGGAGCGGGATGGGGCGGCGGTGTAA