Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1607148..1607734 Replicon chromosome
Accession NZ_CP046582
Organism Erwinia sp. E602

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GKQ23_RS08770 Protein ID WP_249168521.1
Coordinates 1607148..1607438 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GKQ23_RS08775 Protein ID WP_056233399.1
Coordinates 1607435..1607734 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GKQ23_RS08755 (GKQ23_08710) 1603156..1604289 + 1134 WP_212410357.1 fused PTS fructose transporter subunit IIA/HPr protein -
GKQ23_RS08760 (GKQ23_08715) 1604286..1605228 + 943 Protein_1435 1-phosphofructokinase -
GKQ23_RS08765 (GKQ23_08720) 1605245..1606939 + 1695 WP_056233401.1 PTS fructose transporter subunit IIBC -
GKQ23_RS08770 (GKQ23_08725) 1607148..1607438 + 291 WP_249168521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GKQ23_RS08775 (GKQ23_08730) 1607435..1607734 + 300 WP_056233399.1 helix-turn-helix transcriptional regulator Antitoxin
GKQ23_RS08780 (GKQ23_08735) 1607863..1608711 - 849 WP_056233397.1 deoxyribonuclease IV -
GKQ23_RS08785 (GKQ23_08740) 1608997..1609869 + 873 WP_101506267.1 DNA-binding transcriptional regulator YeiE -
GKQ23_RS08790 (GKQ23_08745) 1610044..1611510 + 1467 WP_212410361.1 amino acid permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(4-87)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-80)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10837.55 Da        Isoelectric Point: 9.6858

>T144530 WP_249168521.1 NZ_CP046582:1607148-1607438 [Erwinia sp. E602]
MIEDVLSSLQTLELFGPRLGRPDVDQIKGSAFKNMRELRVQSNGRPVRAFFAFDPLRMAIVLCAGDKTGQKSKRFYSEMI
KIADAEYTKHLEGIST

Download         Length: 291 bp

>T144530 NZ_CP062122:c5425444-5425088 [Pseudomonas sp. ADPe]
ATGGTGAGGCGCCCGCCGAGCGTTCCCAACCGCGGTGAGATCTGGCACTTGCAGTTCGATCCCTCGACGGGCCGTGAAAT
GATCGGCGACCACTTTTGCCTGGTCCTGTCGAAACGCGAATTCAATGAAATGGGCTTGGCCCTGGTCTGCCCCATCTCGC
AAGGCGCATCCAATGTGGCGCGCAACCAGGGCTTCCTTGTCACCCTGATGGGCGAAGGCACCGATACCCAGGGCAATGTC
CACAGCCACCAGGTGCGGACGCTGGACTGGAGGGCGCGCCGAGCCGCATTCAAGGAAAAGGCCCCCGATTCCGTAACCAA
CTACGTGCTTTCGCTGGTCGGGGCGATCCTGGAGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11017.76 Da        Isoelectric Point: 9.9995

>AT144530 WP_056233399.1 NZ_CP046582:1607435-1607734 [Erwinia sp. E602]
MTKLSQLIAERSAESQQRIREKTEAKILEIRLRQLREEQHLSQSELAAKMGVSQPAITAIESRGEEIKLATLKKYVEALG
GKVSLNIEMPGGSGRIYPV

Download         Length: 300 bp

>AT144530 NZ_CP062122:c5425677-5425438 [Pseudomonas sp. ADPe]
ATGACCACGCTTGCCCTGCGCAAATCCGGGGGGTCCCTGATCATTTCGGTTCCCTCGGCCTTCGTCGCCCAGAACAAACT
GCACGCTGGCAGTCAGGTTGAGTGCGACATCGTTGAGGGAGCCCTGGTGATCAAGCCGATGACGCGCCCGAGCCTGGCCC
AACTGATCGCCGAAACGCCCAAAGACTCGCTCGCCCCGGACTGGGACAGCATGCCGGCCGTAGGCGCGGAACAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References