144524

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 185642..186987 Replicon chromosome
Accession NZ_CP046582
Organism Erwinia sp. E602

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag GKQ23_RS02230 Protein ID WP_249168466.1
Coordinates 186091..186987 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag GKQ23_RS02225 Protein ID WP_212409663.1
Coordinates 185642..185956 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GKQ23_RS02200 (GKQ23_02195) 181524..182165 + 642 WP_056241168.1 hydrolase -
GKQ23_RS02205 (GKQ23_02200) 182205..182789 + 585 WP_212409660.1 antibiotic biosynthesis monooxygenase -
GKQ23_RS02210 (GKQ23_02205) 182782..184650 + 1869 WP_056232787.1 amidohydrolase -
GKQ23_RS02215 (GKQ23_02210) 184718..185119 - 402 WP_212409661.1 VOC family protein -
GKQ23_RS02220 (GKQ23_02215) 185331..185657 + 327 WP_212409662.1 helix-turn-helix transcriptional regulator -
GKQ23_RS02225 (GKQ23_02220) 185642..185956 + 315 WP_212409663.1 HipA N-terminal domain-containing protein Antitoxin
GKQ23_RS02230 (GKQ23_02225) 186091..186987 + 897 WP_249168466.1 HipA domain-containing protein Toxin
GKQ23_RS02235 (GKQ23_02230) 187050..189422 - 2373 WP_212409665.1 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family -
GKQ23_RS02240 189493..189672 + 180 WP_212409666.1 hypothetical protein -
GKQ23_RS02245 (GKQ23_02235) 189891..190958 + 1068 WP_212409667.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(11-258)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 33792.65 Da        Isoelectric Point: 4.5599

>T144524 WP_249168466.1 NZ_CP046582:186091-186987 [Erwinia sp. E602]
VQELPQKQKGMSISGYQPKLQMILQDLEFTVIDKQGEYILKPSPVEFPRLAENEHATMTLMSRLGFDVPPCGLLAFRSEQ
AGDEEEYAFVIKRFDRTAGGKGVHHEQLDAAMDIDEKYGKIADDGKSWISYEQIARFLVANVNDNLAFRIDLFRRIVYAY
LLGNNDMHLRNFGLLLPQDKPPQLSPLYDFVSVVPYQAYFTAPLALPLLACEEGDKALAGGFSTRYGEYLGMDFLVLAES
IGLSKRLTAALLTDLVKEQEIVESTYRESFMPEDDVEAVLRYYRSRLSRLQILDEPAL

Download         Length: 897 bp

>T144524 NZ_CP062122:3794649-3795014 [Pseudomonas sp. ADPe]
ATGGTGAAGGCGCTGTTCGACACCAACGTCCTCATCGACTACCTCAACGGCCACGAACAGGCCCGCGACGAGTTGCGCCG
CTACGATGACCCCGCCATCAGCATCGTCACCTGGATGGAGGTGATGATCGGCGCCACGCCCGCCACCGCCGCGGCCACCC
GCGCCTTCCTCGACAGCTTCGCCCTGGTGCCGCTCGACGCGCCCGTCGCCGAGCGCGCCGTGGCGGTGCGCCAGGCGCTG
CGGGTGAAGCTGCCGGACGCCATCATCAAGGCCAGCGCCGAGGTGCAGGGGCGCCTGCTGGTCACCCGCAACACCAGGGA
CTTCCCCGTCGACGACGCCGGCGTGCGCCTGCCCTACCGGCTCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12015.73 Da        Isoelectric Point: 9.4513

>AT144524 WP_212409663.1 NZ_CP046582:185642-185956 [Erwinia sp. E602]
MRRRVTVWLYDRPVGVLSQNEQGYLFEYHADYAGPALSLSLPVERRSFPRATLHPFFASLAPEGWLKRRYSQLQKIDERD
LLGLLINNGENLLGAVRLSVEERS

Download         Length: 315 bp

>AT144524 NZ_CP062122:3794440-3794655 [Pseudomonas sp. ADPe]
ATGCGTACCCTGGTCGACATCCCCGCCGAACATCTCGAGGCGCTCAACGCCCTGGGCGAGCAACAGCAGCAATCGCGCGC
CGCGCTGATCCGCGAGGCGGTCGCCGAGTACCTGGTCCGGCACCGCCGGCAGGATGCCGAGGCCGCCTTCGGCCTGTGGA
ACGGCAGCGCCGGCGACGGCCTGGCCTACCAGGAGAAGGTACGCGAGGAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References