Detailed information of TA system TA144522

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 119067..119721
• Replicon: chromosome
• Accession: NZ_CP046582
• Organism: Erwinia sp. E602

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: GKQ23_RS01895
• Protein ID: WP_212409623.1
• Coordinates: 119350..119721 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: GKQ23_RS01890
• Protein ID: WP_212409622.1
• Coordinates: 119067..119369 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GKQ23_RS01875 (GKQ23_01875)	114685..115980	+	1296	WP_212409620.1	alginate lyase family protein	-
GKQ23_RS01880 (GKQ23_01880)	116132..116908	+	777	WP_056240733.1	cyclic-guanylate-specific phosphodiesterase	-
GKQ23_RS01885 (GKQ23_01885)	116967..119027	+	2061	WP_212409621.1	AsmA family protein	-
GKQ23_RS01890 (GKQ23_01890)	119067..119369	-	303	WP_212409622.1	XRE family transcriptional regulator	Antitoxin
GKQ23_RS01895 (GKQ23_01895)	119350..119721	-	372	WP_212409623.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GKQ23_RS01900 (GKQ23_01900)	119887..121215	-	1329	WP_212409624.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-81)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 14084.32 Da
• Isoelectric Point: 10.3997

>T144522 WP_212409623.1 NZ_CP046582:c119721-119350 [Erwinia sp. E602]
MWTVLTTELFEQWLWKQDVAIRNKTLATLSLLQKSGPVLGRPLVDSVKGSAFINMKELRIQISGVPWRAFFAFDPLRRAV
ILNAGCKKGDEKRFYSRMVRIADGQFQLHLNSMEGQQDGQNTE

Nucleotide

• Length: 372 bp

>T144522 NZ_CP062122:c2281701-2281366 [Pseudomonas sp. ADPe]
ATGGGCAGCAGCAAGAGGGATCTTCTGGATATGCCTGACGATGTCCAAGATGTGTTCGGCTTTGCCCTGCACCAGGCGCA
GGAAGGTGGCAAGCATCCCCAGACCAAGCCGATGAAAGGCTTCTCGGGGGCCGGCGTGCTGGAGGTTGTCGAAGACCATG
ATGGCGACACCTATCGAGCGGTCTACACAGTGAAATTTGCAAGGGCGGTCTATGCTCTGCACTGCTTCCAGAAGAAATCG
ACCAAGGGCATAGAGACTCCGCAGCACGACCTGGAGCTGATCAGGAAAAGGCTGAAGGATGCGCAAGCCCATGCGAAGAG
CGTAGAGAATGATTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11608.27 Da
• Isoelectric Point: 4.9001

>AT144522 WP_212409622.1 NZ_CP046582:c119369-119067 [Erwinia sp. E602]
MGRTLNEILAQLPDEDRQEINDLTRQLELEYHLYQLRERLNLTQRDLAQQMGISQPTVAAMEKRGQDLKLITLKRYVEAL
GGEVKVDVRLADGEHFIFSL

Nucleotide

• Length: 303 bp

>AT144522 NZ_CP062122:c2281373-2281053 [Pseudomonas sp. ADPe]
ATGATTGAGTTCGAAGAAGGCAGCGGCAACGTCTATGCCGACCTCGGCAGGGCCGATGCAGGCGAGATGCAGGTCAAGGC
CAGGCTGGCATCCAAGATCGGCAGCATCATCAAGGCCCGCCACTTGACCCAGACCCAGGCGGCGGAAATCCTCGGGCTCC
CTCAACCCAAGGTTTCCGACATGTTGCGTGGGAAATTCAGAGGCATCAGCGAGGCCAAGATGATCGACTGCCTGGCCCGG
CTCGGACGTGACGTGCAGATCGTGGTCAAGGCCGCACCCCGCTCACGCCGTGAGGGCCGGGTGGAAGTAGTCTTCGCCTG
A