Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 821280..821788 Replicon plasmid pRWAY01
Accession NZ_CP046573
Organism Rhodococcus sp. WAY2

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6P1IBG8
Locus tag GFS60_RS33770 Protein ID WP_072948949.1
Coordinates 821528..821788 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q0RYC5
Locus tag GFS60_RS33765 Protein ID WP_005569061.1
Coordinates 821280..821531 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFS60_RS33740 816501..817288 - 788 Protein_758 hypothetical protein -
GFS60_RS33745 818076..818372 - 297 Protein_759 phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase family protein -
GFS60_RS33750 818481..819194 + 714 WP_159928774.1 LppX_LprAFG lipoprotein -
GFS60_RS33755 819191..820765 + 1575 WP_159928776.1 MFS transporter -
GFS60_RS33760 820834..821233 - 400 Protein_762 hypothetical protein -
GFS60_RS33765 821280..821531 + 252 WP_005569061.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GFS60_RS33770 821528..821788 + 261 WP_072948949.1 Txe/YoeB family addiction module toxin Toxin
GFS60_RS33775 822604..824310 - 1707 WP_159928780.1 DEAD/DEAH box helicase -
GFS60_RS33785 825136..825294 + 159 WP_159928782.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..991117 991117


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10412.81 Da        Isoelectric Point: 8.8670

>T144518 WP_072948949.1 NZ_CP046573:821528-821788 [Rhodococcus sp. WAY2]
MKLVWDESAWEDYVWWQAQDRKIVKRINTLLKDVERNGNDGIGKPEPLKHGFQGYWSRRITDEHRLVYKIVDDQIRIAAC
RYHYGH

Download         Length: 261 bp

>T144518 NZ_CP062122:c1285979-1285410 [Pseudomonas sp. ADPe]
ATGTTCAGACCGTCACCCATCACCCTGCAGCGCGGTGCGCTGCGCCTGGAGCCCATGGTCGAGGCCGACGTGCCGGACCT
GGTGGCGCTGGCCGAGGCCAATCGCGAGGCGCTGAAGTTCATGAGCGCGCCGCAGCGCCCGGACTGGTACCGCAACAGCC
TCGCCGAGCAGCGCGAGGGCCGCGCCCTGCCGCTGGTGGTGCGCCTGGGCAACCAGCTGGTGGGCACCACCCGCTTCATG
GACTTCCTCCCGGCGCTGCCGGCCTGCGAGATCGGCGGCACCTGGCTGGATGCGGCGCAGCACGGCACCGGGCTGAACGC
CAGCATCAAGTACCTGATGCTGCGCCAGGCCTTCGACAACTGGAAGATGGTCCGCGTGCAGCTGAAGACCGCCGCCAGCA
ACCTGCGCTCGCAGCGCGCCATCGAGAAGCTCGGCGCGGTGCGCGAGGGCGTGCTGCGCAACCACCGGCGCCTGGCCGGC
GGGCGCCTGGACGACAGCGTTCTCTACAGCATCACCGACCTGGAGTGGCCGCAGGTGAAGGCCGCCCTGGAAGCCGGCTT
CATCGGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9358.50 Da        Isoelectric Point: 4.5216

>AT144518 WP_005569061.1 NZ_CP046573:821280-821531 [Rhodococcus sp. WAY2]
MRTMTYSESRARYAEVLNAVVDDREEIVITRAGHEPVVMVSLDDYESLKETAYLLRSPENARRLLASIDRLESGGGTVRD
LAE

Download         Length: 252 bp

>AT144518 NZ_CP062122:c1285400-1284540 [Pseudomonas sp. ADPe]
ATGCCCCTCGACAGCGCCCATGGCGAGCGCACGCGCTTCTGGCGGGCCCAGGAACTGGGCGGGCTGGAGTTGCTGCACGC
GCGCTTCATCGAGCAGCGCTTCGCCCCCCACGTCCACGAGGGCTTCGCCCTGGTGCTGATCGAGCAGGGCGCCCAGCGCT
TCCGCCACCGCGGCGCCGAGCACCTGGCGCCCAGCGGCAGCCTGGTGCTGATCAATCCCGATGAGGTGCACACCGGCTCC
AAGGCCCATGAGGCGGGCTGGTTGTACCGGGGGTTCTATCCGGAGATCGGGCAGGTCGGCAGCGTGCTCGACGAGCTGGA
GCTGGGCGGCCGCGGCCTGCCGACCTTCGACGCCAGCGTGTTGCACGATCCCGAGCTGAGCCGTGCCTTCCTGCACGTGC
ACCGCCTGCTGGAATCCAATGCCAGCAGCCTGGAGCGCCAGACCTGCTGGCGCGAGGCATTGCTGTTGCTGTTCCAGCGC
CACGCGCGGGTGCCCGAAGCGCGCCCGGCCGGACAGGAACCCCAGGCGGTGGCCCGCGCCCGCGAGCTGCTGGCCGCCCG
GCTGGTCGAGCCGCCATCGCTGGAAGAACTGGCGGCGGCGGTGAACCTGTCGCCCTTCCACTTCGCCCGGGTGTTCCGCA
AGGCCACCGGCCTGCCGCCCCACGCCTGGATCAAGCAACGCCGCCTGGAACAGGCCCGCGCCCTGCTCAAGGGCGGCTGC
GCGCCGGCCTCGGTGGCGGCGCAACTGGGCTACGCCGACCAGAGTCACCTGAGCCGCCAGTTCAAGCAGGCCTACGGCGT
GGCGCCGGGGGAATACCGCCAGGCTTGCGGACGCTCCGGCCTGCCACCCGGCAACCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1IBG8

Antitoxin

Source ID Structure
AlphaFold DB Q0RYC5

References