Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5473147..5473814 Replicon chromosome
Accession NZ_CP046572
Organism Rhodococcus sp. WAY2

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag GFS60_RS24590 Protein ID WP_159925334.1
Coordinates 5473147..5473503 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag GFS60_RS24595 Protein ID WP_043790214.1
Coordinates 5473509..5473814 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFS60_RS24570 5468219..5468623 - 405 WP_159925328.1 hypothetical protein -
GFS60_RS24575 5468640..5468888 - 249 Protein_4871 protein kinase -
GFS60_RS24580 5469359..5470885 + 1527 WP_159925330.1 permease -
GFS60_RS24585 5470942..5471577 + 636 WP_159925332.1 cysteine hydrolase -
GFS60_RS38685 5472038..5472340 - 303 WP_201453646.1 RGCVC family protein -
GFS60_RS24590 5473147..5473503 + 357 WP_159925334.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GFS60_RS24595 5473509..5473814 + 306 WP_043790214.1 XRE family transcriptional regulator Antitoxin
GFS60_RS38690 5474211..5474513 - 303 WP_201453646.1 RGCVC family protein -
GFS60_RS24600 5474766..5475008 + 243 WP_159927511.1 GNAT family N-acetyltransferase -
GFS60_RS24605 5475068..5475352 - 285 WP_159925336.1 hypothetical protein -
GFS60_RS24610 5476175..5476693 + 519 WP_159925338.1 hypothetical protein -
GFS60_RS24615 5476690..5477337 + 648 WP_159925340.1 hypothetical protein -
GFS60_RS24620 5477408..5477704 - 297 WP_159927512.1 hypothetical protein -
GFS60_RS24625 5478317..5478604 - 288 WP_159925342.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-108)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13262.33 Da        Isoelectric Point: 9.9595

>T144516 WP_159925334.1 NZ_CP046572:5473147-5473503 [Rhodococcus sp. WAY2]
VGKWTVEVGLVEEWLLALDQSSYEQVVAALELLAERGPQLGRPLVDAVKASRHKNMKELRPGSSGRSELRVLFAFDPERK
AILLVAGNKAGRWKTWYKLNIPIADDRFAAHLDELKGR

Download         Length: 357 bp

>T144516 NZ_CP062120:c137531-137250 [Aminobacter sp. SR38]
ATGCGGCAGATTGAGCGCACCGGCCAGTTCAAGCGCGACTACAAGCGCGAGGCGAAAGGGCAGCACCGGGCCACGCTCGA
CGCCGACCTGGTGCCCGTCCTGGTCGCGCTCGCCGACGACCAGCCGCTGGAACCTCGGCACCGCGACCACGCGCTGACCG
GGGACTGGAAGGATCACCGGGATTGCCACGTCAAGCCCGACCTGGTGCTGATCTACCAGAAGCCCGACGCCGACACGCTG
CGCCTGGTGCGCCTCGGCTCTCACTCCGAACTCGGCTTGTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11501.11 Da        Isoelectric Point: 5.7791

>AT144516 WP_043790214.1 NZ_CP046572:5473509-5473814 [Rhodococcus sp. WAY2]
MAKSLEQMLAERPVDRGAVEAHKARMIDEVRAYRLQELRESVAMTQKQLAERLGVGQNRVSNIEHGDLERVQIDTLRRYV
EAVGGALRVEVELGDERFQIA

Download         Length: 306 bp

>AT144516 NZ_CP062120:c137781-137518 [Aminobacter sp. SR38]
ATGGCTGCAAACCAGCTCGTACAAACGCGCATCGACGGCGCGATCAAGGAAGAAGCGGCGGCCGTCCTGGCCGCGATGGG
CCTTACCGTGTCCGACGCGGTGCGGCTGCTGCTCACGAAGGTGGCCCAGGACAAGGCGCTGCCCTTCGAGCCGCTGATTC
CGAACGCCACCACCATCGAGGCGATGAAGGAAGCCCGCAAGGGCAAGCTGCCGCGCTTCGCCACCGTCAACGATCTGATG
GCCGATCTGCATGCGGCAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References