Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1196703..1197352 Replicon chromosome
Accession NZ_CP046557
Organism Leclercia sp. 1106151

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GNG29_RS05625 Protein ID WP_156654025.1
Coordinates 1196990..1197352 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GNG29_RS05620 Protein ID WP_103178550.1
Coordinates 1196703..1197002 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNG29_RS05610 1193193..1195166 + 1974 WP_156654024.1 PhoX family phosphatase -
GNG29_RS05615 1195270..1196658 + 1389 WP_103178549.1 phenylalanine transporter -
GNG29_RS05620 1196703..1197002 - 300 WP_103178550.1 XRE family transcriptional regulator Antitoxin
GNG29_RS05625 1196990..1197352 - 363 WP_156654025.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GNG29_RS05630 1197606..1198844 + 1239 WP_103181038.1 MFS transporter -
GNG29_RS05635 1198859..1199884 + 1026 WP_156654026.1 sugar phosphate isomerase/epimerase -
GNG29_RS05640 1199877..1201019 + 1143 WP_103178553.1 Gfo/Idh/MocA family oxidoreductase -
GNG29_RS05645 1201095..1202069 + 975 WP_103178554.1 LacI family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13994.92 Da        Isoelectric Point: 7.3567

>T144499 WP_156654025.1 NZ_CP046557:c1197352-1196990 [Leclercia sp. 1106151]
MWEVETTDMFDEWFHHQKQDLKEDVLAALHILSEYGPQLGRPWVDTVKASQYTNMKELRIQHAGDPIRAFFAFDPGRQAI
TLCAGNKTVAGDKRFYKRMINIADAEFSKYLASKEAKWQR

Download         Length: 363 bp

>T144499 NZ_CP062008:3024910-3025485 [Mycolicibacterium mucogenicum DSM 44124]
GTGAAACGCCTGGACCTCGTCGTCGGCTCGAACGGTGCCGGAAAATCGACGTTCGTCGAACTCACGCTGGCTCCGCTGCT
CCCCCGCAGCGTGTTCGTCAACGCCGATGAGATCGCCAAACAGCGTTGGCCTGCCGACGCATTGGGCCACGCGTACGAGG
CCGCGCGGATCGCTGCGGCGACGCGGGAAGCGCTGATCGAGCAGGGGCGTTCATTCATCGCCGAGACAGTGTTTTCGCAC
CCCTCCAAGCTGGAGCTGATCGATGCGGCCCGTCATGCGGGGTACGTCGTGGTGTTGCACATTGTGCTTGTTCCCGAAGA
CTTGGCCGTTCACCGTGTCCGCTACCGGGTTGCCGCCGGTGGCCACGATGTGCCCGAGGAGAAGATCCGGGAACGGTATC
GCCGGCTGTGGGCCCTGGTGGCTGCAGCGATCGTTCGCGTCGACAGCGCAACGATTTACGACAATTCCGCGGCCAGCGGA
CCGCAGATCGTGGCGCAGATGAGTGGCGGACTGAGTGTCGACACGCCCCGATGGCCGTCGTGGACTCCGGAGCAGCTGCG
TAGTCGCTGGCCGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10971.70 Da        Isoelectric Point: 5.1667

>AT144499 WP_103178550.1 NZ_CP046557:c1197002-1196703 [Leclercia sp. 1106151]
MATLKELMAQQSEESQERIAAKVEELRIIVALNQLREELNMSQTELAAAMGVKQPTVAKIEQPDNDPRLSTLKRYVTALG
GEVSIDVILPTGKRVAFHI

Download         Length: 300 bp

>AT144499 NZ_CP062008:3024512-3024913 [Mycolicibacterium mucogenicum DSM 44124]
ATGTCCGACGTCGCTGATCGGGTCACCCGGGTCGCCGCTGACCTTTTCGAGGCCGCGGCCGCTGAGGGCGCCCGGCAGAG
TCGCTCTGCCAAGCAGCAACTCGACCATTGGGCCCGGGTGGGCCGCGCTGTATCGACTCAGCACACCGCCTCACGGCGCC
GGGTCGAGGCTGCCCTCGCCGGCCAGATCGACGTCGCCGTCCTCAACACCGAAGAAGGCGTGGTGTTCAACGCCGAGGTT
TCCGCGTCTATCGAGGAGAGCCTGGCCCGCACCGATTACGGTGCCGTGCTCGCCTCTCGTGGGATCACCACGGTGGCACT
GGATGAGGACGGCCAGATCGTCGAGCATCGCCCTGACGGCACCGAGTCCGTGGTTGGCGCGGTGCAGTCGCTGCGTCGGT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References