Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 60252..60898 Replicon chromosome
Accession NZ_CP046557
Organism Leclercia sp. 1106151

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GNG29_RS00310 Protein ID WP_103177685.1
Coordinates 60548..60898 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GNG29_RS00305 Protein ID WP_156653669.1
Coordinates 60252..60551 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNG29_RS00280 55985..57073 - 1089 WP_156653667.1 AAA family ATPase -
GNG29_RS00285 57218..58177 - 960 WP_103177681.1 DUF523 and DUF1722 domain-containing protein -
GNG29_RS00290 58280..58690 - 411 WP_114385495.1 hydroxyisourate hydrolase -
GNG29_RS00295 58787..59515 - 729 WP_156653668.1 MerR family transcriptional regulator -
GNG29_RS00300 59633..60157 + 525 WP_103177683.1 lipocalin family protein -
GNG29_RS00305 60252..60551 - 300 WP_156653669.1 XRE family transcriptional regulator Antitoxin
GNG29_RS00310 60548..60898 - 351 WP_103177685.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GNG29_RS00315 61009..61446 + 438 WP_156653670.1 acetyltransferase -
GNG29_RS00320 61519..62040 - 522 WP_103181009.1 hypothetical protein -
GNG29_RS00325 62369..62656 - 288 WP_156653671.1 SymE family type I addiction module toxin -
GNG29_RS00330 62785..62961 + 177 WP_156653672.1 DUF3950 domain-containing protein -
GNG29_RS00335 63006..63698 - 693 WP_156653673.1 nucleotidyltransferase domain-containing protein -
GNG29_RS00340 63695..64897 - 1203 WP_156653674.1 pentapeptide repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13547.46 Da        Isoelectric Point: 7.2761

>T144495 WP_103177685.1 NZ_CP046557:c60898-60548 [Leclercia sp. 1106151]
MWTVILGEVFEAWLEDQEQGVQEKVFAALINLQTYGPRLPRPYADTVRGSRHNNMKELRIQYYGRPIRAFFAFDPVRQAI
VLCAGDKSHDKKFYERLIRIADDEFSAHLAAMETRN

Download         Length: 351 bp

>T144495 NZ_CP062005:1819866-1820189 [Halomonas sp. YLGW01]
ATGAGGCGTGGGGATCTCGTGACCATTGCCCTATCGGGTGATTTCGGTAAGCCGCGTCCCGCCCTCATCGTCCAGTCCGA
CCAGTTTGCCGGCACAGGCAGTGTGACGGTGCTGCTGCTCTCCAGAAGCCGGGTCAATGCACCGTTGATCCGCCTCGATG
TTGAGCCCACCCCCGAGAACGGCTTGCACCGACGCTCCCAGATCATGGTGGACAAACCCATGACGGTGAAACGCGAGAGA
GTTGGAGAGTACTTCGGTCACCTCGATGACAGCGCCATGGTCGCCGTCAACAGAGCGCTGGCCGTCTTCCTGGGCTTCGC
GTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11195.12 Da        Isoelectric Point: 8.6049

>AT144495 WP_156653669.1 NZ_CP046557:c60551-60252 [Leclercia sp. 1106151]
MKTLNEAIASRSPESQKRIKEMADEMILETGLQMMREELKLSQKHVAEVMGISQPAITQLEQRGNELKITTLKRYIEAMG
GKLSLDVELPTGKRVAFHI

Download         Length: 300 bp

>AT144495 NZ_CP062005:1819633-1819869 [Halomonas sp. YLGW01]
ATGGTGGCTACGAACGATGTAAACAACAGGGTGAAGAAGCACCGCGGCGCCTTGCGAGCGGCCGGCCTGCGCCCGATCCA
AATCTGGGTCCCGGACACTCGACAACCCGGCTTCGCCGAAGAGGCTCACCGTCAGTGCGCTCTCGTGGCAGCTGCCGACG
CCGGGGATCGCGACCTGCAGGACTTCATGGACGCGGCTCTGCTGGATCTTGACCTGGATGACGAGGGTGACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References