Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 2370020..2370561 Replicon chromosome
Accession NZ_CP046539
Organism Escherichia coli strain FHI_NMBU_10

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag GOE21_RS11885 Protein ID WP_000615982.1
Coordinates 2370283..2370561 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag GOE21_RS11880 Protein ID WP_000729704.1
Coordinates 2370020..2370280 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOE21_RS11855 2365803..2366588 - 786 WP_000207568.1 putative lateral flagellar export/assembly protein LafU -
GOE21_RS11860 2366560..2368272 + 1713 Protein_2321 flagellar biosynthesis protein FlhA -
GOE21_RS11865 2368377..2368655 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
GOE21_RS11870 2368648..2369004 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
GOE21_RS11875 2369061..2369834 - 774 WP_000543899.1 C40 family peptidase -
GOE21_RS11880 2370020..2370280 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
GOE21_RS11885 2370283..2370561 + 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
GOE21_RS11890 2370717..2371457 + 741 WP_001225679.1 murein L,D-transpeptidase -
GOE21_RS11895 2371428..2372195 - 768 WP_000333380.1 class II glutamine amidotransferase -
GOE21_RS11900 2372401..2372979 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T144482 WP_000615982.1 NZ_CP046539:2370283-2370561 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T144482 NZ_CP061975:1912200-1912302 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT144482 WP_000729704.1 NZ_CP046539:2370020-2370280 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT144482 NZ_CP061975:c1912309-1912164 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References