Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3077725..3078242 Replicon chromosome
Accession NZ_CP046535
Organism Sphingomonas sp. LMO-1

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag GNT64_RS14740 Protein ID WP_156680213.1
Coordinates 3077976..3078242 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag GNT64_RS14735 Protein ID WP_156680212.1
Coordinates 3077725..3077979 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNT64_RS14710 3073760..3075628 + 1869 WP_156680207.1 ABC-F family ATP-binding cassette domain-containing protein -
GNT64_RS14715 3075821..3076420 + 600 WP_197277000.1 hypothetical protein -
GNT64_RS14720 3076408..3076869 - 462 WP_197277001.1 hypothetical protein -
GNT64_RS14725 3077028..3077249 + 222 WP_156680210.1 hypothetical protein -
GNT64_RS14730 3077279..3077617 - 339 WP_156680211.1 hypothetical protein -
GNT64_RS14735 3077725..3077979 + 255 WP_156680212.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GNT64_RS14740 3077976..3078242 + 267 WP_156680213.1 Txe/YoeB family addiction module toxin Toxin
GNT64_RS14745 3078364..3080241 - 1878 WP_156680214.1 phosphomethylpyrimidine synthase ThiC -
GNT64_RS14750 3080418..3080807 - 390 WP_156681664.1 DUF2141 domain-containing protein -
GNT64_RS14755 3080767..3081516 - 750 WP_156681663.1 sterol desaturase family protein -
GNT64_RS14760 3081772..3082950 + 1179 WP_156680215.1 lycopene beta-cyclase CrtY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10240.58 Da        Isoelectric Point: 9.6032

>T144466 WP_156680213.1 NZ_CP046535:3077976-3078242 [Sphingomonas sp. LMO-1]
VNVQFSSRSWVEYLNLHADDAKLFAKLHALIEECRRHPFRGTGKPEPLGGNLTGWWSRRINQEHRLVYRVVGSGAEQTLQ
VAQCRYQY

Download         Length: 267 bp

>T144466 NZ_CP061970:741843-742220 [Klebsiella pneumoniae]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCAACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9260.51 Da        Isoelectric Point: 4.6487

>AT144466 WP_156680212.1 NZ_CP046535:3077725-3077979 [Sphingomonas sp. LMO-1]
MQTVSYSEARENLKAMIDKVVADRAPLTITRQRGEGAVLISESEWASIEETLYLLRSPANAKRLLESIAELEAGGGEVHE
LIHP

Download         Length: 255 bp

>AT144466 NZ_CP061970:741385-741753 [Klebsiella pneumoniae]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCATGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGGTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References