Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 3558655..3559325 | Replicon | chromosome |
Accession | NZ_CP046529 | ||
Organism | Mycobacterium tuberculosis strain SIT745/EAI1-MYS |
Toxin (Protein)
Gene name | higB | Uniprot ID | O53332 |
Locus tag | AYJ03_RS16825 | Protein ID | WP_003899954.1 |
Coordinates | 3558655..3558999 (+) | Length | 115 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | G0THF6 |
Locus tag | AYJ03_RS16830 | Protein ID | WP_003899955.1 |
Coordinates | 3558996..3559325 (+) | Length | 110 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AYJ03_RS16790 | 3553728..3554588 | + | 861 | WP_003416628.1 | alpha/beta hydrolase | - |
AYJ03_RS16795 | 3554563..3555078 | + | 516 | WP_003899950.1 | nitroreductase family deazaflavin-dependent oxidoreductase | - |
AYJ03_RS16805 | 3555318..3555611 | + | 294 | WP_003416635.1 | hypothetical protein | - |
AYJ03_RS16810 | 3555899..3557188 | + | 1290 | WP_003416640.1 | ATP-binding protein | - |
AYJ03_RS16815 | 3557535..3557969 | - | 435 | WP_003899952.1 | type II toxin-antitoxin system VapC family toxin | - |
AYJ03_RS16820 | 3557972..3558424 | - | 453 | WP_003899953.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
AYJ03_RS16825 | 3558655..3558999 | + | 345 | WP_003899954.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
AYJ03_RS16830 | 3558996..3559325 | + | 330 | WP_003899955.1 | XRE family transcriptional regulator | Antitoxin |
AYJ03_RS16835 | 3559871..3560218 | + | 348 | WP_003899956.1 | DUF2384 domain-containing protein | - |
AYJ03_RS16840 | 3560215..3560835 | + | 621 | WP_003899957.1 | RES family NAD+ phosphorylase | - |
AYJ03_RS16845 | 3560995..3562260 | - | 1266 | WP_003912135.1 | hypothetical protein | - |
AYJ03_RS16850 | 3562428..3562637 | + | 210 | WP_003416778.1 | hypothetical protein | - |
AYJ03_RS16860 | 3562884..3563918 | - | 1035 | WP_003416786.1 | IS30 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 12692.50 Da Isoelectric Point: 5.6920
>T144456 WP_003899954.1 NZ_CP046529:3558655-3558999 [Mycobacterium tuberculosis]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG
Download Length: 345 bp
>T144456 NZ_CP061965:c3082886-3082784 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 110 a.a. Molecular weight: 11802.46 Da Isoelectric Point: 7.4051
>AT144456 WP_003899955.1 NZ_CP046529:3558996-3559325 [Mycobacterium tuberculosis]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA
Download Length: 330 bp
>AT144456 NZ_CP061965:3082777-3082922 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4FBK2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0THF6 |