144456

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3558655..3559325 Replicon chromosome
Accession NZ_CP046529
Organism Mycobacterium tuberculosis strain SIT745/EAI1-MYS

Toxin (Protein)


Gene name higB Uniprot ID O53332
Locus tag AYJ03_RS16825 Protein ID WP_003899954.1
Coordinates 3558655..3558999 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0THF6
Locus tag AYJ03_RS16830 Protein ID WP_003899955.1
Coordinates 3558996..3559325 (+) Length 110 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYJ03_RS16790 3553728..3554588 + 861 WP_003416628.1 alpha/beta hydrolase -
AYJ03_RS16795 3554563..3555078 + 516 WP_003899950.1 nitroreductase family deazaflavin-dependent oxidoreductase -
AYJ03_RS16805 3555318..3555611 + 294 WP_003416635.1 hypothetical protein -
AYJ03_RS16810 3555899..3557188 + 1290 WP_003416640.1 ATP-binding protein -
AYJ03_RS16815 3557535..3557969 - 435 WP_003899952.1 type II toxin-antitoxin system VapC family toxin -
AYJ03_RS16820 3557972..3558424 - 453 WP_003899953.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
AYJ03_RS16825 3558655..3558999 + 345 WP_003899954.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AYJ03_RS16830 3558996..3559325 + 330 WP_003899955.1 XRE family transcriptional regulator Antitoxin
AYJ03_RS16835 3559871..3560218 + 348 WP_003899956.1 DUF2384 domain-containing protein -
AYJ03_RS16840 3560215..3560835 + 621 WP_003899957.1 RES family NAD+ phosphorylase -
AYJ03_RS16845 3560995..3562260 - 1266 WP_003912135.1 hypothetical protein -
AYJ03_RS16850 3562428..3562637 + 210 WP_003416778.1 hypothetical protein -
AYJ03_RS16860 3562884..3563918 - 1035 WP_003416786.1 IS30 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-103)

Antitoxin

(38-91)


Sequences


Toxin        


Download         Length: 115 a.a.        Molecular weight: 12692.50 Da        Isoelectric Point: 5.6920

>T144456 WP_003899954.1 NZ_CP046529:3558655-3558999 [Mycobacterium tuberculosis]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG

Download         Length: 345 bp

>T144456 NZ_CP061965:c3082886-3082784 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11802.46 Da        Isoelectric Point: 7.4051

>AT144456 WP_003899955.1 NZ_CP046529:3558996-3559325 [Mycobacterium tuberculosis]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA

Download         Length: 330 bp

>AT144456 NZ_CP061965:3082777-3082922 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U4FBK2


Antitoxin

Source ID Structure
AlphaFold DB G0THF6

References