Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2981343..2981991 Replicon chromosome
Accession NZ_CP046529
Organism Mycobacterium tuberculosis strain SIT745/EAI1-MYS

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag AYJ03_RS14005 Protein ID WP_003899414.1
Coordinates 2981343..2981666 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag AYJ03_RS14010 Protein ID WP_003899415.1
Coordinates 2981746..2981991 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYJ03_RS13980 2976662..2977660 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
AYJ03_RS13985 2977674..2978138 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
AYJ03_RS13990 2978552..2979991 - 1440 WP_009935349.1 phage major capsid protein -
AYJ03_RS13995 2979999..2980532 - 534 WP_003899412.1 HK97 family phage prohead protease -
AYJ03_RS14000 2980685..2981176 - 492 WP_003900541.1 phage terminase small subunit P27 family -
AYJ03_RS14005 2981343..2981666 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
AYJ03_RS14010 2981746..2981991 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
AYJ03_RS14015 2981988..2983415 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
AYJ03_RS14020 2983417..2983809 - 393 WP_003899417.1 DUF2742 domain-containing protein -
AYJ03_RS14025 2983806..2984066 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
AYJ03_RS14030 2984083..2984445 - 363 WP_003900543.1 hypothetical protein -
AYJ03_RS14035 2984448..2985575 - 1128 WP_003899420.1 site-specific integrase -
AYJ03_RS14040 2985720..2985947 - 228 WP_003899421.1 hypothetical protein -
AYJ03_RS14045 2985944..2986333 - 390 WP_003899422.1 hypothetical protein -
AYJ03_RS14050 2986239..2986511 + 273 WP_003900544.1 hypothetical protein -
AYJ03_RS14055 2986610..2986843 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2976662..2985575 8913


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T144448 WP_003899414.1 NZ_CP046529:c2981666-2981343 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T144448 NZ_CP061962:61462-61905 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT144448 WP_003899415.1 NZ_CP046529:c2981991-2981746 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT144448 NZ_CP061962:61235-61465 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References