Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2206187..2207055 | Replicon | chromosome |
| Accession | NZ_CP046529 | ||
| Organism | Mycobacterium tuberculosis strain SIT745/EAI1-MYS | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | AYJ03_RS10275 | Protein ID | WP_010886136.1 |
| Coordinates | 2206187..2206564 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | AYJ03_RS10280 | Protein ID | WP_003409886.1 |
| Coordinates | 2206606..2207055 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AYJ03_RS10225 | 2201976..2202428 | - | 453 | WP_003899095.1 | lipoprotein | - |
| AYJ03_RS10230 | 2202492..2202893 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| AYJ03_RS10235 | 2202886..2203068 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| AYJ03_RS10240 | 2203182..2203532 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| AYJ03_RS10245 | 2203543..2204445 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| AYJ03_RS10250 | 2204466..2204657 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| AYJ03_RS10255 | 2204658..2204954 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| AYJ03_RS10260 | 2205194..2205409 | + | 216 | WP_003409878.1 | antitoxin | - |
| AYJ03_RS10265 | 2205406..2205717 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| AYJ03_RS20770 | 2205691..2206212 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| AYJ03_RS10275 | 2206187..2206564 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| AYJ03_RS10280 | 2206606..2207055 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| AYJ03_RS10285 | 2207052..2207597 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| AYJ03_RS10290 | 2207486..2208100 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| AYJ03_RS10295 | 2208149..2208445 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| AYJ03_RS10300 | 2208442..2208693 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| AYJ03_RS10305 | 2208680..2209174 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| AYJ03_RS10310 | 2209334..2209741 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| AYJ03_RS10315 | 2209745..2210017 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| AYJ03_RS10320 | 2210050..2211270 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T144433 WP_010886136.1 NZ_CP046529:2206187-2206564 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T144433 NZ_CP061960:c9791-9375 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT144433 WP_003409886.1 NZ_CP046529:2206606-2207055 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT144433 NZ_CP061960:c10018-9788 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|