Detailed information of TA system TA144384

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3796538..3796763
• Replicon: chromosome
• Accession: NZ_CP046527
• Organism: Escherichia coli strain RM19259

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: GN312_RS18620
• Protein ID: WP_000813263.1
• Coordinates: 3796608..3796763 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3796538..3796596 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GN312_RS18590	3791807..3792904	+	1098	WP_001475117.1	hypothetical protein	-
GN312_RS18595	3792911..3793657	+	747	WP_000788745.1	ATP-binding protein	-
GN312_RS18600	3793679..3794449	+	771	WP_000450992.1	DUF1627 domain-containing protein	-
GN312_RS18605	3794465..3794878	+	414	WP_001151233.1	DUF977 family protein	-
GN312_RS18610	3795230..3796003	-	774	WP_000160654.1	alpha/beta hydrolase	-
-	3796538..3796596	-	59	-	-	Antitoxin
GN312_RS18620	3796608..3796763	+	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
GN312_RS18625	3796931..3797209	+	279	WP_001341388.1	hypothetical protein	-
GN312_RS18630	3797211..3798260	+	1050	WP_001265172.1	DUF968 domain-containing protein	-
GN312_RS18635	3798273..3798644	+	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
GN312_RS18640	3798634..3799005	+	372	WP_000090264.1	antitermination protein	-
GN312_RS18645	3799157..3799975	+	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
GN312_RS18650	3800262..3800458	+	197	Protein_3527	TrmB family transcriptional regulator	-
GN312_RS18655	3800596..3801309	+	714	WP_000261909.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T144384 WP_000813263.1 NZ_CP046527:3796608-3796763 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T144384 NZ_CP061941:2491468-2491746 [Marinomonas algicola]
ATGATTTTATGGGAAGAAGAATCGCTAAATGATCGTGAGAAGATCTTTGAGTTTCTTTATGACTTCAACCCTGATGCGGC
AGACAAAACTGACGAAATTATCGAAGCTAAAGTAGAAAATTTACTTGAGCAACCATTAATGGGTGTTCAACGTGATGGTA
TTCGAGGACGACTACTCATTATCCCCGAAATCTCAATGATCGTTTCTTACTGGGTTGACGGCTCAGCTATTCGCGTAATG
CGAGTTCTACACCAGAAGCAAAAATTCCCTACCGACTGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT144384 NZ_CP046527:c3796596-3796538 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin