Detailed information of TA system TA144370

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 1588811..1589032
• Replicon: chromosome
• Accession: NZ_CP046527
• Organism: Escherichia coli strain RM19259

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: GN312_RS08445
• Protein ID: WP_001295224.1
• Coordinates: 1588811..1588918 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	1588967..1589032 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GN312_RS08420	1584064..1584816	-	753	Protein_1537	cellulose biosynthesis protein BcsQ	-
GN312_RS08425	1584828..1585016	-	189	WP_001063316.1	YhjR family protein	-
GN312_RS08430	1585289..1586860	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
GN312_RS08435	1586857..1587048	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
GN312_RS08440	1587045..1588724	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
GN312_RS08445	1588811..1588918	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	1588967..1589032	+	66	NuclAT_16	-	Antitoxin
-	1588967..1589032	+	66	NuclAT_16	-	Antitoxin
-	1588967..1589032	+	66	NuclAT_16	-	Antitoxin
-	1588967..1589032	+	66	NuclAT_16	-	Antitoxin
-	1588967..1589032	+	66	NuclAT_21	-	Antitoxin
-	1588967..1589032	+	66	NuclAT_21	-	Antitoxin
-	1588967..1589032	+	66	NuclAT_21	-	Antitoxin
-	1588967..1589032	+	66	NuclAT_21	-	Antitoxin
GN312_RS08450	1589394..1590665	+	1272	WP_001301684.1	amino acid permease	-
GN312_RS08455	1590695..1591699	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
GN312_RS08460	1591696..1592679	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
GN312_RS08465	1592690..1593592	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T144370 WP_001295224.1 NZ_CP046527:c1588918-1588811 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T144370 NZ_CP061930:2233975-2234283 [Klebsiella michiganensis]
ATGCAGTATTACGTTTATAAGAATACAGGTCGAATTGCTGCGTATCCTTACCTCCTTGATGTACAGAGTGACATTATCGG
CAAGCGCAATACTCGGGTCGTGATTCCACTGTTTCCACTGAAAAACTATAAAGGCCCACGCGCCGATCGTTTAACACCGC
TTGTCACCGTAGAAGGGGAAGAATACGTCGTGATGACTCACGAACTCGCCAGCATCCCACATCGTGTTCTGGGTGAAGAA
GTTTGTAATCTGAATCACCAGCGCGAAGTCGTTAAAGCTTCAATGGATTTTCTTTTCGACGGGATCTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT144370 NZ_CP046527:1588967-1589032 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin