Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1515769..1516281 Replicon chromosome
Accession NZ_CP046524
Organism Streptococcus oralis strain SOT

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag GOM47_RS07660 Protein ID WP_070535801.1
Coordinates 1515769..1516023 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag GOM47_RS07665 Protein ID WP_193432073.1
Coordinates 1516027..1516281 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOM47_RS07640 (GOM47_07635) 1511060..1511374 - 315 WP_002874282.1 DNA-directed RNA polymerase subunit omega -
GOM47_RS07645 (GOM47_07640) 1511399..1512025 - 627 WP_000775041.1 guanylate kinase -
GOM47_RS07650 (GOM47_07645) 1512160..1513773 - 1614 WP_235080413.1 ribonuclease Y -
GOM47_RS07655 (GOM47_07650) 1513900..1515567 - 1668 WP_235080414.1 P-loop NTPase fold protein -
GOM47_RS07660 (GOM47_07655) 1515769..1516023 - 255 WP_070535801.1 Txe/YoeB family addiction module toxin Toxin
GOM47_RS07665 (GOM47_07660) 1516027..1516281 - 255 WP_193432073.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GOM47_RS07670 (GOM47_07665) 1516413..1517510 - 1098 WP_235080415.1 nucleotidyltransferase -
GOM47_RS07675 (GOM47_07670) 1517520..1518266 - 747 WP_084922214.1 class I SAM-dependent methyltransferase -
GOM47_RS07680 (GOM47_07675) 1518582..1518935 - 354 WP_049479124.1 ribosome silencing factor -
GOM47_RS07685 (GOM47_07680) 1518936..1519529 - 594 WP_000331220.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
GOM47_RS07690 (GOM47_07685) 1519529..1520158 - 630 WP_000963714.1 nicotinate-nucleotide adenylyltransferase -
GOM47_RS07695 (GOM47_07690) 1520210..1520521 - 312 WP_049519347.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10145.64 Da        Isoelectric Point: 7.9716

>T144361 WP_070535801.1 NZ_CP046524:c1516023-1515769 [Streptococcus oralis]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFVGMGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSIAFLSF
KDHY

Download         Length: 255 bp

>T144361 NZ_CP061914:3917614-3917892 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9766.11 Da        Isoelectric Point: 4.8430

>AT144361 WP_193432073.1 NZ_CP046524:c1516281-1516027 [Streptococcus oralis]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIVQNKELSDKVLRGMAQVRAGSTQVH
MIEE

Download         Length: 255 bp

>AT144361 NZ_CP061914:3917351-3917611 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References