Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 404210..404858 Replicon chromosome
Accession NZ_CP046523
Organism Streptococcus oralis strain SOD

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GOM48_RS01970 Protein ID WP_235098036.1
Coordinates 404210..404575 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1X0WZS6
Locus tag GOM48_RS01975 Protein ID WP_049504738.1
Coordinates 404565..404858 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOM48_RS01945 (GOM48_01940) 400010..401056 + 1047 WP_235098028.1 hypothetical protein -
GOM48_RS01950 (GOM48_01945) 401034..402248 + 1215 WP_235098029.1 ATP-binding protein -
GOM48_RS01955 (GOM48_01950) 402442..403221 + 780 WP_007517765.1 hypothetical protein -
GOM48_RS01960 (GOM48_01955) 403303..403704 + 402 WP_235098032.1 YbgA family protein -
GOM48_RS01965 (GOM48_01960) 403688..404053 + 366 WP_235098034.1 TIGR02328 family protein -
GOM48_RS01970 (GOM48_01965) 404210..404575 + 366 WP_235098036.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GOM48_RS01975 (GOM48_01970) 404565..404858 + 294 WP_049504738.1 helix-turn-helix transcriptional regulator Antitoxin
GOM48_RS01980 (GOM48_01975) 405212..407461 + 2250 WP_235098038.1 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -
GOM48_RS01985 (GOM48_01980) 407556..408422 + 867 WP_235098040.1 methylenetetrahydrofolate reductase [NAD(P)H] -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(35-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14477.52 Da        Isoelectric Point: 9.5341

>T144358 WP_235098036.1 NZ_CP046523:404210-404575 [Streptococcus oralis]
VHTIYFYKDKNGNEPVLDYMRELASQKSKDSRIKLNKLNDYIELLSQYGTRAGEPYIKHSEDEIWELRPLRDRILFVAWL
DGSFVLLHHFAKKTQKTPRREIEKAKRELKNIKERGLSDEE

Download         Length: 366 bp

>T144358 NZ_CP061914:2819642-2819749 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10722.39 Da        Isoelectric Point: 5.1991

>AT144358 WP_049504738.1 NZ_CP046523:404565-404858 [Streptococcus oralis]
MKNSAIGSNWKDIRSELFTKEEILESDMRVAIMSELIEARHEQGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEQEKG

Download         Length: 294 bp

>AT144358 NZ_CP061914:c2819592-2819529 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1X0WZS6

References