Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 372803..373315 Replicon chromosome
Accession NZ_CP046523
Organism Streptococcus oralis strain SOD

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag GOM48_RS01825 Protein ID WP_235098001.1
Coordinates 373061..373315 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag GOM48_RS01820 Protein ID WP_235097998.1
Coordinates 372803..373057 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOM48_RS01790 (GOM48_01785) 368777..369088 + 312 WP_000060171.1 ribosome assembly RNA-binding protein YhbY -
GOM48_RS01795 (GOM48_01790) 369140..369769 + 630 WP_235097989.1 nicotinate-nucleotide adenylyltransferase -
GOM48_RS01800 (GOM48_01795) 369769..370362 + 594 WP_235097991.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
GOM48_RS01805 (GOM48_01800) 370363..370716 + 354 WP_235097993.1 ribosome silencing factor -
GOM48_RS01810 (GOM48_01805) 370824..371564 + 741 WP_235098708.1 class I SAM-dependent methyltransferase -
GOM48_RS01815 (GOM48_01810) 371574..372671 + 1098 WP_235097996.1 nucleotidyltransferase -
GOM48_RS01820 (GOM48_01815) 372803..373057 + 255 WP_235097998.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GOM48_RS01825 (GOM48_01820) 373061..373315 + 255 WP_235098001.1 Txe/YoeB family addiction module toxin Toxin
GOM48_RS01830 (GOM48_01825) 373524..373658 + 135 WP_235098003.1 restriction endonuclease -
GOM48_RS01835 (GOM48_01830) 373705..374160 + 456 WP_235098005.1 KilA-N domain-containing protein -
GOM48_RS01840 (GOM48_01835) 374258..375022 + 765 WP_084910706.1 hypothetical protein -
GOM48_RS01845 (GOM48_01840) 375152..375304 + 153 Protein_329 recombinase family protein -
GOM48_RS01850 (GOM48_01845) 375512..377125 + 1614 WP_235098007.1 ribonuclease Y -
GOM48_RS01855 (GOM48_01850) 377260..377886 + 627 WP_000775041.1 guanylate kinase -
GOM48_RS01860 (GOM48_01855) 377911..378225 + 315 WP_002874282.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10073.57 Da        Isoelectric Point: 6.9740

>T144357 WP_235098001.1 NZ_CP046523:373061-373315 [Streptococcus oralis]
MLLKFTEDAWADYCYWQTQDKKALKRINMLIKDIQRDPFVGMGKPEPLKYDYQGAWSRRIDAENRLIYMIDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T144357 NZ_CP061914:2819107-2819214 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9674.96 Da        Isoelectric Point: 4.6388

>AT144357 WP_235097998.1 NZ_CP046523:372803-373057 [Streptococcus oralis]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLLGLAQVRTGSTQVH
VIEE

Download         Length: 255 bp

>AT144357 NZ_CP061914:c2819054-2818993 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References