Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4622968..4623557 Replicon chromosome
Accession NZ_CP046495
Organism Xanthomonas oryzae pv. oryzae strain IXO597

Toxin (Protein)


Gene name graT Uniprot ID A0A8E2YMU3
Locus tag IXO597_RS21625 Protein ID WP_011260747.1
Coordinates 4623276..4623557 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IXO597_RS21620 Protein ID WP_011260746.1
Coordinates 4622968..4623258 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IXO597_RS21590 (IXO597_021730) 4618112..4618720 - 609 WP_011409746.1 DUF4123 domain-containing protein -
IXO597_RS21595 (IXO597_021735) 4618723..4619145 - 423 WP_042465811.1 PAAR domain-containing protein -
IXO597_RS21600 (IXO597_021740) 4619273..4619599 - 327 WP_228329596.1 hypothetical protein -
IXO597_RS21605 (IXO597_021745) 4619854..4620186 + 333 WP_011260743.1 hypothetical protein -
IXO597_RS21610 4620346..4620533 + 188 Protein_4127 hypothetical protein -
IXO597_RS21615 (IXO597_021755) 4620636..4622030 - 1395 WP_027703652.1 type III secretion system effector XopQ -
IXO597_RS21620 (IXO597_021760) 4622968..4623258 - 291 WP_011260746.1 HigA family addiction module antitoxin Antitoxin
IXO597_RS21625 (IXO597_021765) 4623276..4623557 - 282 WP_011260747.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IXO597_RS21630 (IXO597_021770) 4623652..4625904 - 2253 WP_075243583.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11070.83 Da        Isoelectric Point: 10.2139

>T144345 WP_011260747.1 NZ_CP046495:c4623557-4623276 [Xanthomonas oryzae pv. oryzae]
MIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQQRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Download         Length: 282 bp

>T144345 NZ_CP061914:286745-287020 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATAGTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACAGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10420.07 Da        Isoelectric Point: 7.2040

>AT144345 WP_011260746.1 NZ_CP046495:c4623258-4622968 [Xanthomonas oryzae pv. oryzae]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Download         Length: 291 bp

>AT144345 NZ_CP061914:287017-287376 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References