Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4832849..4833438 Replicon chromosome
Accession NZ_CP046491
Organism Xanthomonas oryzae pv. oryzae strain IXO134

Toxin (Protein)


Gene name graT Uniprot ID G7TIR7
Locus tag IXO134_RS22680 Protein ID WP_012443754.1
Coordinates 4833157..4833438 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IXO134_RS22675 Protein ID WP_011260746.1
Coordinates 4832849..4833139 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IXO134_RS22645 (IXO134_022760) 4828134..4828610 - 477 WP_011260741.1 DUF4123 domain-containing protein -
IXO134_RS22650 (IXO134_022765) 4828613..4829035 - 423 WP_033013301.1 PAAR domain-containing protein -
IXO134_RS22655 (IXO134_022770) 4829163..4829489 - 327 WP_237384726.1 hypothetical protein -
IXO134_RS22660 (IXO134_022775) 4829744..4830076 + 333 WP_011260743.1 hypothetical protein -
IXO134_RS22665 4830236..4830423 + 188 Protein_4332 hypothetical protein -
IXO134_RS22670 (IXO134_022785) 4830526..4831920 - 1395 WP_075240796.1 type III secretion system effector XopQ -
IXO134_RS22675 (IXO134_022790) 4832849..4833139 - 291 WP_011260746.1 HigA family addiction module antitoxin Antitoxin
IXO134_RS22680 (IXO134_022795) 4833157..4833438 - 282 WP_012443754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IXO134_RS22685 (IXO134_022800) 4833533..4835791 - 2259 WP_075240794.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11066.83 Da        Isoelectric Point: 10.5318

>T144340 WP_012443754.1 NZ_CP046491:c4833438-4833157 [Xanthomonas oryzae pv. oryzae]
VIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Download         Length: 282 bp

>T144340 NZ_CP061870:2140507-2140683 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATCATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10420.07 Da        Isoelectric Point: 7.2040

>AT144340 WP_011260746.1 NZ_CP046491:c4833139-4832849 [Xanthomonas oryzae pv. oryzae]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Download         Length: 291 bp

>AT144340 NZ_CP061870:c2140721-2140624 [Bacillus subtilis]
GAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAGCCG
CTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K0GFW5

Antitoxin

Source ID Structure

References