Detailed information of TA system TA144325

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2417798..2417982
• Replicon: chromosome
• Accession: NZ_CP046476
• Organism: Staphylococcus aureus strain MEI001

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: GOL67_RS12015
• Protein ID: WP_000482647.1
• Coordinates: 2417875..2417982 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2417798..2417858 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GOL67_RS12000	2413252..2413419	-	168	WP_001790576.1	hypothetical protein	-
GOL67_RS12005	2413650..2415383	-	1734	WP_000486489.1	ABC transporter ATP-binding protein/permease	-
GOL67_RS12010	2415408..2417171	-	1764	WP_001064814.1	ABC transporter ATP-binding protein/permease	-
-	2417798..2417858	+	61	-	-	Antitoxin
GOL67_RS12015	2417875..2417982	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
GOL67_RS12020	2418116..2418502	-	387	WP_000779360.1	flippase GtxA	-
GOL67_RS12025	2418760..2419902	+	1143	WP_001176863.1	glycerate kinase	-
GOL67_RS12030	2419962..2420621	+	660	WP_000831298.1	membrane protein	-
GOL67_RS12035	2420803..2422014	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
GOL67_RS12040	2422137..2422610	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T144325 WP_000482647.1 NZ_CP046476:c2417982-2417875 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T144325 NZ_CP061850:c4066751-4066341 [Pseudomonas aeruginosa]
ATGCTCAAGTTCATGCTTGACACCAACATCTGCATCTTCACCATCAAAAACCGCCCGCAAGAGGTGCGCGAGGCGTTCCT
GCGCCACCACGACCAGATGTGCATCAGCACCGTGACGCTGATGGAGCTGATCTACGGCGCAGAGAAGTCCTCGAACCCCT
CGCGCAATCTTGCAGACGTGGAAGGCTTCGCTGCTCGTCTGGAGGTGCTCAAGTACGACCAGGAAGCTGCCGCCCACACC
GGCCAGCTCCGCGCTGAACTGGCCCGCCTCGGCAAGCAAATCGGCCCCTATGACCAGATGATCGCCGGGCACGCCCGCTC
TCAGGGCCTGATCGTGGTCACCAATAACCGCCGCGAGTTCGACCGCGTACCCGGCTTGAGAGTTGAGGATTGGGTCACCC
CAATCGTGTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT144325 NZ_CP046476:2417798-2417858 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin