Detailed information of TA system TA144319

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1961232..1961539
• Replicon: chromosome
• Accession: NZ_CP046476
• Organism: Staphylococcus aureus strain MEI001

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: GOL67_RS09575
• Protein ID: WP_072353918.1
• Coordinates: 1961363..1961539 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1961232..1961371 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GOL67_RS09535	1956798..1956977	+	180	WP_000669789.1	hypothetical protein	-
GOL67_RS09540	1957288..1957548	+	261	WP_001791826.1	hypothetical protein	-
GOL67_RS09545	1957601..1957951	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
GOL67_RS09550	1958461..1958796	-	336	Protein_1841	SH3 domain-containing protein	-
GOL67_RS09555	1959448..1959939	-	492	WP_000920041.1	staphylokinase	-
GOL67_RS09560	1960130..1960885	-	756	WP_000861038.1	CHAP domain-containing protein	-
GOL67_RS09565	1960897..1961151	-	255	WP_000611512.1	phage holin	-
GOL67_RS09570	1961203..1961310	+	108	WP_001791821.1	hypothetical protein	-
-	1961232..1961371	+	140	NuclAT_0	-	Antitoxin
-	1961232..1961371	+	140	NuclAT_0	-	Antitoxin
-	1961232..1961371	+	140	NuclAT_0	-	Antitoxin
-	1961232..1961371	+	140	NuclAT_0	-	Antitoxin
GOL67_RS09575	1961363..1961539	-	177	WP_072353918.1	putative holin-like toxin	Toxin
GOL67_RS09580	1961682..1962056	-	375	WP_000340977.1	hypothetical protein	-
GOL67_RS09585	1962112..1962399	-	288	WP_001262620.1	hypothetical protein	-
GOL67_RS09590	1962445..1962597	-	153	WP_001000058.1	hypothetical protein	-
GOL67_RS09595	1962590..1966372	-	3783	WP_001836550.1	phage protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	1957601..2015192	57591

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T144319 WP_072353918.1 NZ_CP046476:c1961539-1961363 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T144319 NZ_CP061849:4562795-4563067 [Chromobacterium haemolyticum]
ATGAAGCTGGCTTGGACGCCTGATGCGGTGGCGGATCGCGAAGCCATTTTTGAATACATTGCAGCAGATAACCCAGCAGC
GGCTCTTGCTCTTGATGAGCTTTTTGAGCAGCAGGCCTCCCGGCTGCTTCTACATCCTGAGTTGGGCCGGGCAGGACGTG
TTGCCGGCACTAGAGAGTGGGTTCTTCATCGCAACTATGTCTGCGTTTACGATTTAGTAACTGATCAACTCCGGGTGCTT
CGGGTTTTACATGTTGCCCGACAACGGCCTTAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT144319 NZ_CP046476:1961232-1961371 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin