Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4791796..4792401 Replicon chromosome
Accession NZ_CP046445
Organism Leclercia sp. 119287

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GNG27_RS23060 Protein ID WP_156264965.1
Coordinates 4792087..4792401 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GNG27_RS23055 Protein ID WP_156264963.1
Coordinates 4791796..4792086 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNG27_RS23040 4789296..4790198 + 903 WP_156264961.1 formate dehydrogenase subunit beta -
GNG27_RS23045 4790195..4790830 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
GNG27_RS23050 4790827..4791756 + 930 WP_142487602.1 formate dehydrogenase accessory protein FdhE -
GNG27_RS23055 4791796..4792086 - 291 WP_156264963.1 helix-turn-helix domain-containing protein Antitoxin
GNG27_RS23060 4792087..4792401 - 315 WP_156264965.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GNG27_RS23065 4792630..4793556 + 927 WP_156264967.1 alpha/beta hydrolase -
GNG27_RS23070 4793724..4794284 + 561 WP_156264969.1 Ail/Lom family outer membrane beta-barrel protein -
GNG27_RS23075 4794351..4795292 - 942 WP_156264971.1 fatty acid biosynthesis protein FabY -
GNG27_RS23080 4795337..4795774 - 438 WP_142487608.1 D-tyrosyl-tRNA(Tyr) deacylase -
GNG27_RS23085 4795771..4796652 - 882 WP_142487609.1 virulence factor BrkB family protein -
GNG27_RS23090 4796646..4797245 - 600 WP_142487610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12251.29 Da        Isoelectric Point: 9.6565

>T144293 WP_156264965.1 NZ_CP046445:c4792401-4792087 [Leclercia sp. 119287]
MLFIETDIFTEDVKKLLDDDEYHKLQVFLAMQPEYGDLIQNTGGLRKIRWLAGGKGGKRSGVRVIYFYRSRENEIRLLLI
YRKGIKDDLSANEKAVLKMIIERW

Download         Length: 315 bp

>T144293 NZ_CP061840:74432-74755 [Legionella pneumophila subsp. pneumophila]
ATGTCTTGGATTGTTGAATTTTATAATGAGTCTGTTGAAGAGGCCATACTTACAATGCCGCCAAAAATTCAGGCTCGAAT
GATTAAACTTTTGGAATTGATTGAAACACATGGCGCTAATCTTGGGCCTCCTCATACAGAAGCGATGGGTGATGGGTTAT
TTGAGATTCGCGCAAAAGCTCAAGAAGGAATCGGGCGATCGCTTTATTGCTATATGAAGGGAAAGCATATTGTGGTTTTG
CATGCATTTGTAAAGAAAAGTGCAAAAACTCCAAAACCAGATTTGCAATTAGCTCTCAAAAGAAAGCGGGAGGTAGAAAA
ATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10631.20 Da        Isoelectric Point: 11.0200

>AT144293 WP_156264963.1 NZ_CP046445:c4792086-4791796 [Leclercia sp. 119287]
MDKALFERLTQSVAQMNEIAGGKREPSRTFQIDAMKIKEIRQASGLSQSKFAQLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp

>AT144293 NZ_CP061840:74752-75036 [Legionella pneumophila subsp. pneumophila]
ATGATGAAACTTAAAACATTAAAGGCTAAAGCGTTAAAAAATCCTGAAGTAAAAGAAGCATACGATGCTTTGGAATCCGA
ATTTGCATTGATCGATGCGTTACTGACGATGCGTCAAAAAGCTGGATTAACTCAAGAAGAGTTAGCTGAGCGAATGGGGA
CAAAAAAAGGGAATATTTCTCGACTGGAAAAAGGAAATACTAATCCAAGCTGGAATACTTTAGAGAAATATGCACATGCG
TGTGGGTTTGATATTTCAATGGCAGTAAAGAGAATCGCTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References