Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3749073..3749784 Replicon chromosome
Accession NZ_CP046445
Organism Leclercia sp. 119287

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GNG27_RS17955 Protein ID WP_156264453.1
Coordinates 3749073..3749396 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GNG27_RS17960 Protein ID WP_156264454.1
Coordinates 3749440..3749784 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNG27_RS17925 3744620..3745567 - 948 WP_156264449.1 LysR family transcriptional regulator -
GNG27_RS17930 3745668..3746102 + 435 WP_142486800.1 DMT family transporter -
GNG27_RS17935 3746107..3746583 + 477 WP_142486801.1 DMT family transporter -
GNG27_RS17940 3746727..3747413 + 687 WP_156264450.1 RluA family pseudouridine synthase -
GNG27_RS17945 3747436..3747819 - 384 WP_156264451.1 VOC family protein -
GNG27_RS17950 3747967..3748860 + 894 WP_156264452.1 PhzF family phenazine biosynthesis protein -
GNG27_RS17955 3749073..3749396 + 324 WP_156264453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GNG27_RS17960 3749440..3749784 + 345 WP_156264454.1 HigA family addiction module antidote protein Antitoxin
GNG27_RS17965 3749860..3750210 - 351 WP_156264455.1 type II toxin-antitoxin system HicB family antitoxin -
GNG27_RS17970 3750203..3750481 - 279 WP_142486808.1 type II toxin-antitoxin system HicA family toxin -
GNG27_RS23545 3750794..3750928 + 135 WP_181247308.1 hypothetical protein -
GNG27_RS17975 3750931..3751359 + 429 WP_156264456.1 hypothetical protein -
GNG27_RS17980 3751425..3751988 + 564 WP_156264457.1 hypothetical protein -
GNG27_RS23550 3752069..3752242 + 174 WP_197090542.1 hypothetical protein -
GNG27_RS17985 3752307..3752825 - 519 WP_156264458.1 hypothetical protein -
GNG27_RS17990 3753411..3753596 + 186 WP_103180815.1 general stress protein -
GNG27_RS17995 3753689..3754183 + 495 WP_106994953.1 ferritin-like domain-containing protein -
GNG27_RS18000 3754215..3754721 + 507 WP_142486811.1 ferritin-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(10-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12227.11 Da        Isoelectric Point: 10.1298

>T144289 WP_156264453.1 NZ_CP046445:3749073-3749396 [Leclercia sp. 119287]
MTTPLTLRSISDFRDTWLEDFFLYGRPHGKIPAEIASALMRKLDIINAATSYRDLRSPPGNKLEALSSPLLGCYSIRVNR
QYRLIFIWSGGKAKGIYLDPHTYNAHR

Download         Length: 324 bp

>T144289 NZ_CP061834:c42297-41881 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13160.12 Da        Isoelectric Point: 6.3288

>AT144289 WP_156264454.1 NZ_CP046445:3749440-3749784 [Leclercia sp. 119287]
MAFTNITRKPTTPGDILLHEFLEPLHLKIADLAEMLNVHRNSVSALVNNNRKLTTDMAVRLARAFDTTIEFWLNLQLNVD
IWEIQHDERMQAEHQQIITAAEMVERKKAQQSVA

Download         Length: 345 bp

>AT144289 NZ_CP061834:c42524-42294 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References