Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2700601..2701191 Replicon chromosome
Accession NZ_CP046444
Organism Granulicella sp. 5B5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GOB94_RS11450 Protein ID WP_182276039.1
Coordinates 2700907..2701191 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag GOB94_RS11445 Protein ID WP_182276038.1
Coordinates 2700601..2700891 (-) Length 97 a.a.

Genomic Context

GOB94_RS11435GOB94_RS11465GOB94_RS11440GOB94_RS11445GOB94_RS11450GOB94_RS11455GOB94_RS11460
Location: 2696070..2699204 (3135 bp)
Type: Others
Protein ID: WP_182276036.1
Location: 2704429..2705646 (1218 bp)
Type: Others
Protein ID: WP_182276042.1
Location: 2699223..2700287 (1065 bp)
Type: Others
Protein ID: WP_182276037.1
Location: 2700601..2700891 (291 bp)
Type: Antitoxin
Protein ID: WP_182276038.1
Location: 2700907..2701191 (285 bp)
Type: Toxin
Protein ID: WP_182276039.1
Location: 2701503..2702843 (1341 bp)
Type: Others
Protein ID: WP_182276040.1
Location: 2702886..2704382 (1497 bp)
Type: Others
Protein ID: WP_182276041.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GOB94_RS114352696070..2699204+3135WP_182276036.1DNA polymerase I-
GOB94_RS114402699223..2700287-1065WP_182276037.1RelA/SpoT domain-containing protein-
GOB94_RS114452700601..2700891-291WP_182276038.1HigA family addiction module antidote proteinAntitoxin
GOB94_RS114502700907..2701191-285WP_182276039.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GOB94_RS114552701503..2702843-1341WP_182276040.1phosphoglucosamine mutase-
GOB94_RS114602702886..2704382-1497WP_182276041.1exodeoxyribonuclease VII large subunit-
GOB94_RS114652704429..2705646+1218WP_182276042.1potassium channel family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(7-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10754.32 Da        Isoelectric Point: 9.7113

>T144269 WP_182276039.1 NZ_CP046444:c2701191-2700907 [Granulicella sp. 5B5]
MILSCRDKRTSEFVAGKMVKAFSGFERAAQMKIDRMQAATSINDLAALPGNRFEALKGDRKGQYSIRINDQWRICFKWPQ
GERGPSDVEIVDYH

Download         Length: 285 bp

>T144269 NZ_CP061802:118461-118769 [Enterobacter mori]
ATGCAATATACCGTTTACCGCAATCCCGGCAACAGCCAGGCATACCCTTACCTGCTGGATATACAGAGCGACATCATTGG
CGAGTTAAATACCCGCCTGGTGATCCCCCTTCATCGGCTTAAAAAAGGAGCCTCGGCCCCGGTTGCGCGATTAACTCCGG
TCATACAGGTGGAAGGGAATGACGTTATCCTGATGACGCATGAAATGGCTTCAGTCCGCGTGAAGCAGCTCGGTCAGGCG
GTCATGGACGCATCTCCGTTCCGGCACACTATCAAAAGTGCGGTGGACTTCCTGCTGGATGGTTTCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10682.41 Da        Isoelectric Point: 9.8632

>AT144269 WP_182276038.1 NZ_CP046444:c2700891-2700601 [Granulicella sp. 5B5]
MGPIHPGEQLAEELEEMGLSAAAFARQIQVPTNRVTEILKGRRSITGDTALRLAHFFGTSAEFWLNLQSLYEIRVAEKKF
GKMIKGLPTIKDLRAA

Download         Length: 291 bp

>AT144269 NZ_CP061802:118219-118458 [Enterobacter mori]
ATGCAGGCTACAGCTGCTCGCCAGAAAAAAACCGTCAGTGTCACCCTTGAGCCAATGCTCGTACAGCAGGCAAAAGACGC
TGGGATTAACTTGTCCGCCACGCTGGCAGAAGCGCTTCAGAGCAAACTGAAGGCCAGTGCAGCGGAAGAATGGAAACGAC
AGAATCGTGCTGGTATTCAGGAGTTGAACCGCATCACTGAAGAGCATGGGTTACTGTCTGACGAATACAGGACGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References