Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1061381..1061964 Replicon chromosome
Accession NZ_CP046415
Organism Guyparkeria halophila strain sp2

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag GM160_RS04900 Protein ID WP_136867002.1
Coordinates 1061381..1061662 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GM160_RS04905 Protein ID WP_197039243.1
Coordinates 1061671..1061964 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GM160_RS04875 1058238..1058843 + 606 WP_156573601.1 CinA family protein -
GM160_RS04880 1058997..1059557 + 561 WP_156573603.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
GM160_RS04885 1059636..1059896 + 261 WP_156575337.1 nucleotidyltransferase domain-containing protein -
GM160_RS04890 1059893..1060381 + 489 WP_156573605.1 hypothetical protein -
GM160_RS04895 1060378..1061310 + 933 WP_156573607.1 regulatory signaling modulator protein AmpE -
GM160_RS04900 1061381..1061662 + 282 WP_136867002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GM160_RS04905 1061671..1061964 + 294 WP_197039243.1 HigA family addiction module antidote protein Antitoxin
GM160_RS04910 1062063..1062713 + 651 WP_156573627.1 histidine phosphatase family protein -
GM160_RS04915 1062710..1063882 + 1173 WP_156573629.1 hypothetical protein -
GM160_RS04920 1063879..1065690 + 1812 WP_156573631.1 single-stranded-DNA-specific exonuclease RecJ -
GM160_RS04925 1066227..1066709 + 483 WP_197039244.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - wbtL 1059893..1096652 36759


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10853.38 Da        Isoelectric Point: 10.9455

>T144227 WP_136867002.1 NZ_CP046415:1061381-1061662 [Guyparkeria halophila]
MIVSFACKDTQRVASGRFSKRLPQQIQRRAKMRLDRIDAARDLDDLRVPPSHRLEALSGDRLGFHSVRINDQWRIVFRWE
QGGAHDVAIVDYH

Download         Length: 282 bp

>T144227 NZ_CP061780:c1016262-1015915 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGTTCCATTCCA
AGGTGAACAGGCTGCATTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11088.64 Da        Isoelectric Point: 6.4644

>AT144227 WP_197039243.1 NZ_CP046415:1061671-1061964 [Guyparkeria halophila]
VMNKRIDPIHPGEHLAEFLDDFGVTQYRLAKEIRVPARRINEIVLGRRGVSADTALRLARFFGTSPDFWMNLQDKYELEV
ARARSGDEIDQIITCSA

Download         Length: 294 bp

>AT144227 NZ_CP061780:c1016523-1016272 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGATCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References