Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3497151..3497760 Replicon chromosome
Accession NZ_CP046400
Organism Pseudodesulfovibrio cashew strain SRB007

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GM415_RS16005 Protein ID WP_158949961.1
Coordinates 3497482..3497760 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GM415_RS16000 Protein ID WP_158949959.1
Coordinates 3497151..3497471 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GM415_RS15970 3492618..3493025 + 408 WP_158949947.1 hypothetical protein -
GM415_RS15975 3493032..3493313 + 282 WP_158949949.1 hypothetical protein -
GM415_RS15980 3493654..3494016 + 363 WP_158949951.1 DUF4160 domain-containing protein -
GM415_RS15985 3494153..3495217 + 1065 WP_158949953.1 nucleoid-associated protein -
GM415_RS15990 3495227..3496201 + 975 WP_158949955.1 RelA/SpoT domain-containing protein -
GM415_RS15995 3496255..3496779 + 525 WP_158949957.1 hypothetical protein -
GM415_RS16000 3497151..3497471 - 321 WP_158949959.1 HigA family addiction module antidote protein Antitoxin
GM415_RS16005 3497482..3497760 - 279 WP_158949961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GM415_RS16010 3498053..3498265 + 213 WP_158949963.1 hypothetical protein -
GM415_RS16015 3498327..3498779 - 453 WP_158949965.1 hypothetical protein -
GM415_RS16020 3498852..3499406 - 555 WP_158949966.1 recombinase family protein -
GM415_RS16025 3499593..3500111 - 519 WP_158949967.1 terminase small subunit -
GM415_RS16030 3500357..3500656 - 300 WP_158949968.1 helix-turn-helix domain-containing protein -
GM415_RS16035 3500649..3501269 - 621 WP_158949969.1 tyrosine-type recombinase/integrase -
GM415_RS16040 3501428..3501733 - 306 WP_158949970.1 hypothetical protein -
GM415_RS16045 3501733..3502476 - 744 WP_158949971.1 helix-turn-helix domain-containing protein -
GM415_RS16050 3502561..3502758 - 198 WP_158949972.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3492780..3505837 13057


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10538.11 Da        Isoelectric Point: 10.2661

>T144182 WP_158949961.1 NZ_CP046400:c3497760-3497482 [Pseudodesulfovibrio cashew]
MIKSFLHKGLEVFFRTGSSKGIQSKHADRLGRMLDRLDAAVEVRDMNAPGYDLHPLKGKLAGHWSVKVSGNWRMTFRMEN
GNAYVVNYLDYH

Download         Length: 279 bp

>T144182 NZ_CP061764:748257-748634 [Escherichia coli O19:H7]
ATGCAAACCCAACCACTATCCTCAACTCAGGAGGCTACACCACGCCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGTTGGATCGTCACTACGGTCTGACACTCAACGACACTCCGTTCGGCAACGATGGCGTGATTCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGATCTGGTACGAACCGACCGTCGCGGTTTT
AACGCAGAAACACAGTCGCCTCTTCTCAGCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGACTGATGACCCGAAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGGGAGGTGCAGCCATGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11873.72 Da        Isoelectric Point: 8.7153

>AT144182 WP_158949959.1 NZ_CP046400:c3497471-3497151 [Pseudodesulfovibrio cashew]
MGTMIRKPTHPGAIIRQDYMEPLSLTVTALAAHLGISRKHLSQVLHERASVTSGLALRLAKAFDTTPDLWLNLQRKRDLW
EAERDTPGLENVEPLPGLQDIGKELR

Download         Length: 321 bp

>AT144182 NZ_CP061764:747847-748206 [Escherichia coli O19:H7]
TTGTCGAATGAAATACCGACAGTAAACCACGATATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGCGCACGGCTGGTACAGGCGGGCAACCGTCTGCATTATCTCGCTGACCGGGCCAACATCACCGGACAGTTCAGCGACG
CTGATTTACGGTATCTCGACCAGGCATTTCCACTGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAAT
CCCTGCCATCAGCACTGTGTCACGCTCTATGCAAAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGT
ATACCTGGCGATTTATCCGACACCAGCGGCAACCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References