Detailed information of TA system TA144170

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3524921..3525142
• Replicon: chromosome
• Accession: NZ_CP046396
• Organism: Escherichia coli strain ampC_0069

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A1D7PZ30
• Locus tag: GNX12_RS16755
• Protein ID: WP_022645587.1
• Coordinates: 3524921..3525028 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3525076..3525142 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GNX12_RS16730	3520765..3521847	+	1083	WP_022645584.1	peptide chain release factor 1	-
GNX12_RS16735	3521847..3522680	+	834	WP_022645585.1	peptide chain release factor N(5)-glutamine methyltransferase	-
GNX12_RS16740	3522677..3523069	+	393	WP_000200374.1	invasion regulator SirB2	-
GNX12_RS16745	3523073..3523882	+	810	WP_022645586.1	invasion regulator SirB1	-
GNX12_RS16750	3523918..3524772	+	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
GNX12_RS16755	3524921..3525028	-	108	WP_022645587.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	3525076..3525142	+	67	NuclAT_28	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_28	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_28	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_28	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_30	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_30	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_30	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_30	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_32	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_32	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_32	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_32	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_34	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_34	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_34	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_34	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_36	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_36	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_36	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_36	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_38	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_38	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_38	-	Antitoxin
-	3525076..3525142	+	67	NuclAT_38	-	Antitoxin
-	3525078..3525135	+	58	NuclAT_41	-	-
-	3525078..3525135	+	58	NuclAT_41	-	-
-	3525078..3525135	+	58	NuclAT_41	-	-
-	3525078..3525135	+	58	NuclAT_41	-	-
-	3525078..3525135	+	58	NuclAT_43	-	-
-	3525078..3525135	+	58	NuclAT_43	-	-
-	3525078..3525135	+	58	NuclAT_43	-	-
-	3525078..3525135	+	58	NuclAT_43	-	-
-	3525078..3525135	+	58	NuclAT_45	-	-
-	3525078..3525135	+	58	NuclAT_45	-	-
-	3525078..3525135	+	58	NuclAT_45	-	-
-	3525078..3525135	+	58	NuclAT_45	-	-
-	3525078..3525135	+	58	NuclAT_47	-	-
-	3525078..3525135	+	58	NuclAT_47	-	-
-	3525078..3525135	+	58	NuclAT_47	-	-
-	3525078..3525135	+	58	NuclAT_47	-	-
GNX12_RS16760	3525456..3525563	-	108	WP_000170956.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	3525616..3525677	+	62	NuclAT_40	-	-
-	3525616..3525677	+	62	NuclAT_40	-	-
-	3525616..3525677	+	62	NuclAT_40	-	-
-	3525616..3525677	+	62	NuclAT_40	-	-
-	3525616..3525677	+	62	NuclAT_42	-	-
-	3525616..3525677	+	62	NuclAT_42	-	-
-	3525616..3525677	+	62	NuclAT_42	-	-
-	3525616..3525677	+	62	NuclAT_42	-	-
-	3525616..3525677	+	62	NuclAT_44	-	-
-	3525616..3525677	+	62	NuclAT_44	-	-
-	3525616..3525677	+	62	NuclAT_44	-	-
-	3525616..3525677	+	62	NuclAT_44	-	-
-	3525616..3525677	+	62	NuclAT_46	-	-
-	3525616..3525677	+	62	NuclAT_46	-	-
-	3525616..3525677	+	62	NuclAT_46	-	-
-	3525616..3525677	+	62	NuclAT_46	-	-
-	3525616..3525678	+	63	NuclAT_29	-	-
-	3525616..3525678	+	63	NuclAT_29	-	-
-	3525616..3525678	+	63	NuclAT_29	-	-
-	3525616..3525678	+	63	NuclAT_29	-	-
-	3525616..3525678	+	63	NuclAT_31	-	-
-	3525616..3525678	+	63	NuclAT_31	-	-
-	3525616..3525678	+	63	NuclAT_31	-	-
-	3525616..3525678	+	63	NuclAT_31	-	-
-	3525616..3525678	+	63	NuclAT_33	-	-
-	3525616..3525678	+	63	NuclAT_33	-	-
-	3525616..3525678	+	63	NuclAT_33	-	-
-	3525616..3525678	+	63	NuclAT_33	-	-
-	3525616..3525678	+	63	NuclAT_35	-	-
-	3525616..3525678	+	63	NuclAT_35	-	-
-	3525616..3525678	+	63	NuclAT_35	-	-
-	3525616..3525678	+	63	NuclAT_35	-	-
-	3525616..3525678	+	63	NuclAT_37	-	-
-	3525616..3525678	+	63	NuclAT_37	-	-
-	3525616..3525678	+	63	NuclAT_37	-	-
-	3525616..3525678	+	63	NuclAT_37	-	-
-	3525616..3525678	+	63	NuclAT_39	-	-
-	3525616..3525678	+	63	NuclAT_39	-	-
-	3525616..3525678	+	63	NuclAT_39	-	-
-	3525616..3525678	+	63	NuclAT_39	-	-
GNX12_RS16765	3525969..3527069	-	1101	WP_001301956.1	sodium-potassium/proton antiporter ChaA	-
GNX12_RS16770	3527339..3527569	+	231	WP_001146444.1	putative cation transport regulator ChaB	-
GNX12_RS16775	3527727..3528422	+	696	WP_012311798.1	glutathione-specific gamma-glutamylcyclotransferase	-
GNX12_RS16780	3528466..3528819	-	354	WP_001169659.1	DsrE/F sulfur relay family protein YchN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4029.82 Da
• Isoelectric Point: 11.4779

>T144170 WP_022645587.1 NZ_CP046396:c3525028-3524921 [Escherichia coli]
MTLAQFAMTFWHDLAAPILAGIITAVIVSWWRNRK

Nucleotide

• Length: 108 bp

>T144170 NZ_CP061758:2410083-2411405 [Escherichia coli O68:H12]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT144170 NZ_CP046396:3525076-3525142 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGGGTTCTC

Structures

Toxin

• AlphaFold DB: A0A1D7PZ30

Antitoxin