144114

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1646719..1648070 Replicon chromosome
Accession NZ_CP046377
Organism Pectobacterium polaris strain PZ1

Toxin (Protein)


Gene name HipT Uniprot ID A0A6P1S2T8
Locus tag GMX10_RS07560 Protein ID WP_039483287.1
Coordinates 1646719..1647759 (-) Length 347 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A6P1S6U4
Locus tag GMX10_RS07565 Protein ID WP_039483284.1
Coordinates 1647756..1648070 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GMX10_RS07540 1642914..1644338 + 1425 WP_161546741.1 hypothetical protein -
GMX10_RS07545 1644551..1644724 - 174 WP_161546742.1 hypothetical protein -
GMX10_RS07550 1644914..1645819 + 906 WP_161546743.1 siderophore-interacting protein -
GMX10_RS07555 1645853..1646608 - 756 WP_161547146.1 thiol:disulfide interchange protein DsbG -
GMX10_RS07560 1646719..1647759 - 1041 WP_039483287.1 HipA domain-containing protein Toxin
GMX10_RS07565 1647756..1648070 - 315 WP_039483284.1 HipA N-terminal domain-containing protein Antitoxin
GMX10_RS07570 1648055..1648270 - 216 WP_111778852.1 helix-turn-helix domain-containing protein -
GMX10_RS07575 1648569..1649702 - 1134 WP_039483273.1 alkylhydroperoxidase domain protein -
GMX10_RS07580 1649699..1650733 - 1035 WP_039483271.1 putative FMN-dependent luciferase-like monooxygenase -
GMX10_RS07585 1650781..1652442 - 1662 WP_161546744.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(57-307)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 347 a.a.        Molecular weight: 39676.76 Da        Isoelectric Point: 6.7797

>T144114 WP_039483287.1 NZ_CP046377:c1647759-1646719 [Pectobacterium polaris]
MIRCRILLTPLTHEEEIATGYSRKGLKHLTGSMHASSTLRFTRQQFMHDLPQAQKGMSISGYQPKIQMVLEERAFTVVDH
QGLYILKPSPIEFPHLAENEHATMTLMARLRFAVPPHGLLRFKPEQADDEPEFAFVIKRFDRDEKTGHPIHQEQLDGAMG
IGEKFGKIHTDGRQYVSYERLALFLSKHVNDNIVFKIDLFRRIAYAYMLGNNDMHLRNFGLIHSRSGSLMLAPIYDFVSV
APYPTYFSSCFMALPLLIQEEGDEALAPGFETAYGEYLGMDFILFGQRIGLSENLTKKLLADFLKEAECVESTYRDSFMP
ADAIETTLRCYRHRLKLMSILDAERI

Download         Length: 1041 bp

>T144114 NZ_CP061749:768309-768650 [Escherichia coli O15:H12]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGCGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCACGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAAAAATTCGGTACGGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11868.62 Da        Isoelectric Point: 8.3774

>AT144114 WP_039483284.1 NZ_CP046377:c1648070-1647756 [Pectobacterium polaris]
MRRQVKVYLYGVHIGQLSQDDEGYLFEYKKSYIGPPLSLSLPIQTGTFHSKTLPPYFASLAPEGWLRRQYSQLQHLDEKD
LFGILIQNGKNLIGAVQLIAEDKS

Download         Length: 315 bp

>AT144114 NZ_CP061749:767971-768288 [Escherichia coli O15:H12]
ATGACCCACATCAACTGGGGCCTGCAGCGGGCTATCACGCCGCGCCTGGGAGCCCGTCTGGTGCAGGAGGGTAACCGACT
GCACTATCTGGCTGACAGGGCCAGCATCACCGGCAGGTTCAGTGACACCGAATGCCGGAAGCTGGATGAAACATGCCCGC
ACTTTATCCGCCAGATGGAGTCGATGCTAACCACCGGTGAACTCAGTCCCCAACACGCCCACTGCGTCACCCTGTACCAC
AACGGTTTCACCTGCGAAGCTGATACTCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1S2T8

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1S6U4

References