Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1518921..1519775 Replicon chromosome
Accession NZ_CP046377
Organism Pectobacterium polaris strain PZ1

Toxin (Protein)


Gene name yhaV Uniprot ID A0A6P1S1D5
Locus tag GMX10_RS07030 Protein ID WP_039487843.1
Coordinates 1518921..1519409 (-) Length 163 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A6P1S4C9
Locus tag GMX10_RS07035 Protein ID WP_039487859.1
Coordinates 1519434..1519775 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GMX10_RS07010 1515444..1516112 + 669 WP_039487849.1 6-phosphogluconate phosphatase -
GMX10_RS07015 1516132..1516860 - 729 WP_039487847.1 amino acid ABC transporter permease -
GMX10_RS07020 1516862..1517605 - 744 WP_039487846.1 amino acid ABC transporter permease -
GMX10_RS07025 1517886..1518722 - 837 WP_039487845.1 ABC transporter substrate-binding protein -
GMX10_RS07030 1518921..1519409 - 489 WP_039487843.1 type II toxin-antitoxin system YhaV family toxin Toxin
GMX10_RS07035 1519434..1519775 - 342 WP_039487859.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
GMX10_RS07040 1520108..1521286 - 1179 WP_039487841.1 benzoate/H(+) symporter BenE family transporter -
GMX10_RS07045 1521378..1521947 + 570 WP_161546729.1 XRE family transcriptional regulator -
GMX10_RS07050 1522008..1522739 - 732 WP_039487837.1 phosphate signaling complex protein PhoU -
GMX10_RS07055 1522752..1523525 - 774 WP_039487836.1 phosphate ABC transporter ATP-binding protein PstB -
GMX10_RS07060 1523612..1524499 - 888 WP_039275952.1 phosphate ABC transporter permease PstA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-148)

Antitoxin

PrlF antitoxin

(15-113)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 18690.49 Da        Isoelectric Point: 6.8563

>T144113 WP_039487843.1 NZ_CP046377:c1519409-1518921 [Pectobacterium polaris]
MEYLDVNGWKICFHSCFLQQIAELAQKVVELKAAKPDEYLGKKETKLLHAIERVIEEWIAVDPLNPQYRQGDTLGDEFKH
WFRAKFLSQFRLFYRCSAEHKTIIIGWVNDFDTLRAYGSKTDAYKVFAGMLRAGEPPDDWEKLLNEAKAITATTSIPGFL
GK

Download         Length: 489 bp

>T144113 NZ_CP061749:708782-709096 [Escherichia coli O15:H12]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12567.24 Da        Isoelectric Point: 4.4335

>AT144113 WP_039487859.1 NZ_CP046377:c1519775-1519434 [Pectobacterium polaris]
MAIQINTADVSLRAESRLTERSQTTIPAAIRDALHLKPGEYIKYTLLAGGKVIMSRQEEEQDDPVVSQFLTFLENDMKKN
PQNIHSIPVAFWESVKALTAGVEVDLDAPLTDD

Download         Length: 342 bp

>AT144113 NZ_CP061749:709093-709509 [Escherichia coli O15:H12]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCGGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCAAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1S1D5

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1S4C9

References