Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3464630..3465132 Replicon chromosome
Accession NZ_CP046376
Organism Pectobacterium parmentieri strain HC

Toxin (Protein)


Gene name yoeB Uniprot ID A0A8B3FFY4
Locus tag GMW39_RS16275 Protein ID WP_025919527.1
Coordinates 3464878..3465132 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A8B3FIJ8
Locus tag GMW39_RS16270 Protein ID WP_033070807.1
Coordinates 3464630..3464881 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GMW39_RS16255 3461052..3462011 + 960 WP_012822281.1 ABC transporter permease -
GMW39_RS16260 3462004..3462870 + 867 WP_012822280.1 ABC transporter permease -
GMW39_RS16265 3462867..3464555 + 1689 WP_161546113.1 ABC transporter ATP-binding protein -
GMW39_RS16270 3464630..3464881 + 252 WP_033070807.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
GMW39_RS16275 3464878..3465132 + 255 WP_025919527.1 Txe/YoeB family addiction module toxin Toxin
GMW39_RS16280 3465190..3466044 - 855 WP_012822276.1 helix-turn-helix domain-containing protein -
GMW39_RS16285 3466069..3466908 - 840 WP_109463696.1 HTH-type transcriptional activator RhaS -
GMW39_RS16290 3467277..3468767 + 1491 WP_012822275.1 rhamnulokinase -
GMW39_RS16295 3468764..3470026 + 1263 WP_012822274.1 L-rhamnose isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10135.66 Da        Isoelectric Point: 8.0367

>T144105 WP_025919527.1 NZ_CP046376:3464878-3465132 [Pectobacterium parmentieri]
VKPIWSEAAWEDYLYWQDIDNRIVKKINELIKEIRRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYAITDDAMMIAAC
RYHY

Download         Length: 255 bp

>T144105 NZ_CP061744:c2254611-2254126 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACCTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGGAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCGGTCTGGCAGTTGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9351.64 Da        Isoelectric Point: 4.6119

>AT144105 WP_033070807.1 NZ_CP046376:3464630-3464881 [Pectobacterium parmentieri]
MRTISYSEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAKRLMNAIESLKAGNGEERD
IIE

Download         Length: 252 bp

>AT144105 NZ_CP061744:c2254865-2254599 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCGGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3FFY4

Antitoxin

Source ID Structure
AlphaFold DB A0A8B3FIJ8

References