Detailed information of TA system TA144095

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1236905..1237427
• Replicon: chromosome
• Accession: NZ_CP046363
• Organism: Macrococcus canis strain Epi0082

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: GL258_RS06445
• Protein ID: WP_138071160.1
• Coordinates: 1236905..1237177 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: GL258_RS06450
• Protein ID: WP_138071162.1
• Coordinates: 1237170..1237427 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GL258_RS06415	1231982..1233229	+	1248	WP_188019008.1	putative DNA binding domain-containing protein	-
GL258_RS06420	1233274..1233720	-	447	WP_188020190.1	GNAT family N-acetyltransferase	-
GL258_RS06425	1233803..1234543	+	741	WP_188019009.1	hypothetical protein	-
GL258_RS06430	1234553..1235443	+	891	WP_188019010.1	phosphotransferase	-
GL258_RS06435	1235629..1236114	+	486	WP_188019011.1	NUDIX domain-containing protein	-
GL258_RS06440	1236120..1236887	+	768	WP_138071158.1	hypothetical protein	-
GL258_RS06445	1236905..1237177	-	273	WP_138071160.1	Txe/YoeB family addiction module toxin	Toxin
GL258_RS06450	1237170..1237427	-	258	WP_138071162.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GL258_RS06455	1237716..1237940	+	225	WP_138071164.1	toxin-antitoxin system, antitoxin component	-
GL258_RS06460	1237937..1238203	+	267	WP_138071166.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GL258_RS06465	1238291..1238800	+	510	WP_138071168.1	hypothetical protein	-
GL258_RS06470	1238961..1240178	+	1218	WP_138071170.1	ATP-binding protein	-
GL258_RS06475	1240314..1241576	+	1263	WP_086042501.1	Y-family DNA polymerase	-
GL258_RS06480	1241723..1241917	+	195	WP_188019012.1	hypothetical protein	-
GL258_RS06485	1242076..1242375	+	300	WP_096076536.1	DUF4298 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10684.42 Da
• Isoelectric Point: 9.7524

>T144095 WP_138071160.1 NZ_CP046363:c1237177-1236905 [Macrococcus canis]
MTKKKILFYSSGFEDYTYWQTNDKTVLKKINKLIKSIMIDGANEGIGKPEKLLGNYTGCYSRRITHEHRLVYKIDDDSIC
ILQCRFHYKR

Nucleotide

• Length: 273 bp

>T144095 NZ_CP061723:c3990532-3990095 [Pseudomonas putida]
GTGATTTTGTGGCGTATCAGCGCCTATGCAGATTTGAGCGGCACTGGGGGGCTGCGTGTTAGCGGACGCTGGCACCAGGC
GGGCCGGCCCGTGGTGTATGCCGCCACCAGCCCTTCCGGGGCGATGCTCGAGGTGCTTGTGCACCTGGAGATCGACCCAG
AGGATTTTCCTACCACCATGCGCCTGATCCGTATCGAATTGCCTGACACGGTTTCACAGGCGCAGTTGCCCGCCCTGCAG
CCCGGCTGGTCCGCTCAGCCTGAGTTGACCCGGGCGCTGGGCAATCGCTTTCTGGATGACTGCTCGGCTTTACTGCTGCC
CGTGCCGAGCGCGATCATGCCCAGCACCATCAACTACCTGTTCAACCCACGGCACGCGCAGGCACAGCGTGCGAAAATCC
AGGTCGAGGATTTTACCCCGGACAGCCGCTTGTTCTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9753.81 Da
• Isoelectric Point: 4.0808

>AT144095 WP_138071162.1 NZ_CP046363:c1237427-1237170 [Macrococcus canis]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTHNAVILSEQDYNSMIETLYLQSTPANAERLQKAIDESIDKNNLLQVE
IDLDD

Nucleotide

• Length: 258 bp

>AT144095 NZ_CP061723:c3990978-3990529 [Pseudomonas putida]
ATGCTTGCCGAAGTGCTTCGTGACAACGGTTACCACGAGTACCGGGCGCGCCTGCAGGCGCTGCTGGAAATACCCGAACT
TGCCAGTGACTTCGAAATCCACACCCGGATCACCCACGGTTTTGCCGCTACCTGGCTGGTGAAGCTGACCGAGCGCGGTG
TGTTCACGCCGGTGGAGCGGGACCAGATCATTCCCCTGCGCACCCTGAAAACCCGTATCGAACGTGACCAGCCGCTGACC
GTGGAAGAGAGTGATCGGCTGTTCCGTTCGGCCCACATCACCGCCATGGCCGAAGCCGTGTTTGGCGAGGCGGACAAGGC
CAAGCGCTGGCTGTCCAAGCCCAAGGAACGTTTTTCGGGGCTGACGCCGATGCAGATGCTCACAACCCAGCAAGGCACCA
CTCAGGTCGAAGAGATGCTGCTGCAGATTGCCGAGGGTTTTGGCCTGTGA