Detailed information of TA system TA144049

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2313857..2314556
• Replicon: chromosome
• Accession: NZ_CP046344
• Organism: Burkholderia multivorans strain FDAARGOS_722

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: J4RFZ0
• Locus tag: FOC30_RS10140
• Protein ID: WP_006413131.1
• Coordinates: 2313857..2314153 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: FOC30_RS10145
• Protein ID: WP_059786238.1
• Coordinates: 2314155..2314556 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC30_RS10125	2310578..2312122	+	1545	WP_196775670.1	sensor domain-containing diguanylate cyclase	-
FOC30_RS10130	2312328..2312600	+	273	WP_012216969.1	hypothetical protein	-
FOC30_RS10135	2312703..2313737	+	1035	WP_155821908.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
FOC30_RS10140	2313857..2314153	+	297	WP_006413131.1	type II toxin-antitoxin system MqsR family toxin	Toxin
FOC30_RS10145	2314155..2314556	+	402	WP_059786238.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
FOC30_RS10150	2314857..2315417	+	561	WP_059786242.1	GNAT family N-acetyltransferase	-
FOC30_RS10155	2315483..2316424	+	942	WP_039217954.1	ABC transporter substrate-binding protein	-
FOC30_RS10160	2316456..2317517	+	1062	WP_155821909.1	LLM class flavin-dependent oxidoreductase	-
FOC30_RS10165	2317514..2318866	+	1353	WP_006413139.1	LLM class flavin-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11199.10 Da
• Isoelectric Point: 9.1122

>T144049 WP_006413131.1 NZ_CP046344:2313857-2314153 [Burkholderia multivorans]
MEKRTPHCKLPRVKALIEAGKVRLTASAVIGARQMGFTEAETIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVVDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T144049 NZ_CP061699:50421-50702 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTGGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14507.65 Da
• Isoelectric Point: 7.0834

>AT144049 WP_059786238.1 NZ_CP046344:2314155-2314556 [Burkholderia multivorans]
MKCPACGAATLVRDTRDIPYTYKGESTVIPHVTGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKLLDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT144049 NZ_CP061699:50197-50424 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAGCACGCCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• AlphaFold DB: A0A132ERQ0